2. PROTAC Apoptosis
  3. PROTACs c-Myc
  4. MDEG-541

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein.

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MDEG-541 Chemical Structure

MDEG-541 Chemical Structure

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Based on 1 publication(s) in Google Scholar

MDEG-541 Related Antibodies

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Description

MDEG-541 is a potent MYC-MAX degrader. MDEG-541 is a PROTAC that based on the MYC-MAX dimerization inhibitor 10058-F4 derivative 28RH and Thalidomide (HY-14658). MDEG-541 shows antiproliferative activity. MDEG-541 decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein[1].

In Vitro

MDEG-541 (10 µM; 3, 12, 24 h) decreases the expression of GSPT1, MYC, GSPT2, PLK1 protein in a time-dependent manner in KP4 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDEG-541 Related Antibodies

Western Blot Analysis[1]

Cell Line: HCT116, PSN1 cells
Concentration: 5, 10, 20 µM
Incubation Time: 24 h
Result: Decreased the expression of MYC in a dose-dependent manner.

Cell Viability Assay[1]

Cell Line: HCT116, PSN1 cells
Concentration: 0-50 µM
Incubation Time: 72 h
Result: Inhibited cell viability with GI50s of 14.3, 10.7 µM for HCT116, PSN1 cells, respectively.
Molecular Weight

674.83

Formula

C35H38N4O6S2
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CC2=C(C(N(C(CC3)C(NC3=O)=O)C2=O)=O)C=C1)NCCCCCCCCN(C/4=O)C(SC4=C/C5=CC=C(C(C)C)C=C5)=S
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 116.67 mg/mL (172.89 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.4819 mL 7.4093 mL 14.8185 mL
5 mM 0.2964 mL 1.4819 mL 2.9637 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.4819 mL 7.4093 mL 14.8185 mL 37.0464 mL
5 mM 0.2964 mL 1.4819 mL 2.9637 mL 7.4093 mL
10 mM 0.1482 mL 0.7409 mL 1.4819 mL 3.7046 mL
15 mM 0.0988 mL 0.4940 mL 0.9879 mL 2.4698 mL
20 mM 0.0741 mL 0.3705 mL 0.7409 mL 1.8523 mL
25 mM 0.0593 mL 0.2964 mL 0.5927 mL 1.4819 mL
30 mM 0.0494 mL 0.2470 mL 0.4940 mL 1.2349 mL
40 mM 0.0370 mL 0.1852 mL 0.3705 mL 0.9262 mL
50 mM 0.0296 mL 0.1482 mL 0.2964 mL 0.7409 mL
60 mM 0.0247 mL 0.1235 mL 0.2470 mL 0.6174 mL
80 mM 0.0185 mL 0.0926 mL 0.1852 mL 0.4631 mL
100 mM 0.0148 mL 0.0741 mL 0.1482 mL 0.3705 mL
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MDEG-541 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDEG-541MDEG541MDEG 541PROTACsc-MycMycantiproliferativeGSPT1MYCGSPT2PLK1HCT116PSN1KP4 cellsInhibitorinhibitorinhibit

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