2. Apoptosis
  3. MDM-2/p53
  4. MDM2-IN-1

MDM2-IN-1 (Compound 30) is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration.

For research use only. We do not sell to patients.

MDM2-IN-1 Chemical Structure

MDM2-IN-1 Chemical Structure

CAS No. : 1410737-09-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 305 In-stock
Solution
10 mM * 1 mL in DMSO USD 321 In-stock
Solid
5 mg USD 315 In-stock
10 mg USD 504 In-stock
25 mg USD 998 In-stock
50 mg USD 1523 In-stock
100 mg USD 2363 In-stock
200 mg   Get quote  
500 mg   Get quote  

Get it by April 8 for select sizes. Order within 12 hrs 44 mins.

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Based on 1 publication(s) in Google Scholar

MDM2-IN-1 Related Antibodies

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Description

MDM2-IN-1 (Compound 30) is a synthetic MDM2-p53 interaction (MDM2) inhibitor and contains the trans (D-)configuration[1].

Molecular Weight

463.33

Formula

C23H21Cl2FN2O3
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C([C@H](N1)[C@H](C2=CC=CC(Cl)=C2F)[C@]3(C(NC4=C3C=CC(Cl)=C4)=O)C51CCCCC5)O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 22 mg/mL (47.48 mM; ultrasonic and warming and heat to 80°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

DMF : 10 mg/mL (21.58 mM; ultrasonic and warming and heat to 60°C)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1583 mL 10.7914 mL 21.5829 mL
5 mM 0.4317 mL 2.1583 mL 4.3166 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.25 mg/mL (4.86 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.25 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (22.5 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, PEG300/PEG400, Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Purity & Documentation

Purity: 98.02%

Data Sheet (276 KB) SDS (252 KB)

COA (258 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / DMSO 1 mM 2.1583 mL 10.7914 mL 21.5829 mL 53.9572 mL
5 mM 0.4317 mL 2.1583 mL 4.3166 mL 10.7914 mL
10 mM 0.2158 mL 1.0791 mL 2.1583 mL 5.3957 mL
15 mM 0.1439 mL 0.7194 mL 1.4389 mL 3.5971 mL
20 mM 0.1079 mL 0.5396 mL 1.0791 mL 2.6979 mL
DMSO 25 mM 0.0863 mL 0.4317 mL 0.8633 mL 2.1583 mL
30 mM 0.0719 mL 0.3597 mL 0.7194 mL 1.7986 mL
40 mM 0.0540 mL 0.2698 mL 0.5396 mL 1.3489 mL
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MDM2-IN-1 Related Classifications

Keywords:

MDM2-IN-11410737-09-5MDM-2/p53Trans-configurationInhibitorinhibitorinhibit

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Product Name:
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