2. Apoptosis
  3. MDM-2/p53
  4. MDM2-p53-IN-16

MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research.

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MDM2-p53-IN-16 Chemical Structure

MDM2-p53-IN-16 Chemical Structure

CAS No. : 1917350-09-4

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Based on 1 publication(s) in Google Scholar

MDM2-p53-IN-16 Related Antibodies

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Description

MDM2-p53-IN-16 is a MDM2-p53 complex inhibitor with an IC50 value of 4.3 nM to dissociate human p53/MDM2 complex. MDM2-p53-IN-16 reactivates p53, and induces Glioblastoma Multiforme (GBM) cell apoptosis and cell-cycle arrest. MDM2-p53-IN-16 can be used for the cancer research[1].

In Vitro

MDM2-p53-IN-16 (0.01 nM-100 μM; 1 hour) dissociates MDM2-p53 interaction with an IC50 value of 4.3 nM[1].
MDM2-p53-IN-16 (1 µM; 8 hours) significantly increases the levels of p53 in GBM cells[1].
MDM2-p53-IN-16 (1 µM; 6 hours) increases the mRNA levels of p53 target genes: MDM2, PUMA and p21 in U87MG cells[1].
MDM2-p53-IN-16 binds with translocator protein (TSPO) with a Ki value of 87.2 nM[1].
MDM2-p53-IN-16 (1 µM; 24 hours) induces early and late apoptosis and cell cycle arrest of U87MG cells[1].
MDM2-p53-IN-16 (1-10000 nM; 48 h) shows antiproliferative activities to U87MG and wild-type p53 U343MG cells with IC50 values of 1.2 and 1.6 μM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MDM2-p53-IN-16 Related Antibodies

Cell Proliferation Assay[1]

Cell Line: U87MG, U343MG and T98G cell lines
Concentration: 1-10000 nM
Incubation Time: 48 hours
Result: Inhibited cell proliferation of U87MG, U343MG and T98G cells.

Apoptosis Analysis[1]

Cell Line: U87MG cell line
Concentration: 1 µM
Incubation Time: 24 hours
Result: Induced cell apoptosis of U87MG cells.

Cell Cycle Analysis[1]

Cell Line: U87MG, U343MG and T98G cell lines
Concentration: 1-10000 nM
Incubation Time: 48 hours
Result: Induced cell cycle arrest progression in the G2/M-phase of U87MG cells.
Molecular Weight

539.62

Formula

C32H33N3O5
CAS No.
Appearance

Solid

Color

Light green to green

SMILES

O=C(N[C@@H](CC1=CC=CC=C1)C(N[C@@H](CC(C)C)C(OC)=O)=O)C(C2=C(C3=CC=CC=C3)NC4=C2C=CC=C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (185.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8532 mL 9.2658 mL 18.5316 mL
5 mM 0.3706 mL 1.8532 mL 3.7063 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8532 mL 9.2658 mL 18.5316 mL 46.3289 mL
5 mM 0.3706 mL 1.8532 mL 3.7063 mL 9.2658 mL
10 mM 0.1853 mL 0.9266 mL 1.8532 mL 4.6329 mL
15 mM 0.1235 mL 0.6177 mL 1.2354 mL 3.0886 mL
20 mM 0.0927 mL 0.4633 mL 0.9266 mL 2.3164 mL
25 mM 0.0741 mL 0.3706 mL 0.7413 mL 1.8532 mL
30 mM 0.0618 mL 0.3089 mL 0.6177 mL 1.5443 mL
40 mM 0.0463 mL 0.2316 mL 0.4633 mL 1.1582 mL
50 mM 0.0371 mL 0.1853 mL 0.3706 mL 0.9266 mL
60 mM 0.0309 mL 0.1544 mL 0.3089 mL 0.7721 mL
80 mM 0.0232 mL 0.1158 mL 0.2316 mL 0.5791 mL
100 mM 0.0185 mL 0.0927 mL 0.1853 mL 0.4633 mL
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MDM2-p53-IN-16 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MDM2-p53-IN-161917350-09-4MDM-2/p53GBMapoptosiscell cycle arrestcancerTSPOU87MGU343MGInhibitorinhibitorinhibit

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