2. Apoptosis
  3. MDM-2/p53
  4. MeOIstPyrd

MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction.

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MeOIstPyrd Chemical Structure

MeOIstPyrd Chemical Structure

CAS No. : 2308548-54-9

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25 mg USD 560 In-stock
50 mg USD 900 In-stock
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Based on 1 publication(s) in Google Scholar

MeOIstPyrd Related Antibodies

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Description

MeOIstPyrd is an anti-skin cancer agent. MeOIstPyrd inhibits cell proliferation, migration, and spheroid formation by activating the mitochondrial intrinsic apoptotic pathway. MeOIstPyrd induces DNA damage. MeOIstPyrd activates p53, and increases the half-life of p53 and stabilizes p53 by phosphorylating it at ser15. MeOIstPyrd binds to MDM2 in the p53 sub-pocket and blocks p53-MDM2 interaction[1].

Molecular Weight

304.37

Formula

C14H16N4O2S
CAS No.
Appearance

Solid

Color

Orange to reddish brown

SMILES

COC1=CC=C(NC(/C2=N\NC(N3CCCC3)=S)=O)C2=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

DMSO : 16.67 mg/mL (54.77 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2855 mL 16.4274 mL 32.8548 mL
5 mM 0.6571 mL 3.2855 mL 6.5710 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2855 mL 16.4274 mL 32.8547 mL 82.1369 mL
5 mM 0.6571 mL 3.2855 mL 6.5709 mL 16.4274 mL
10 mM 0.3285 mL 1.6427 mL 3.2855 mL 8.2137 mL
15 mM 0.2190 mL 1.0952 mL 2.1903 mL 5.4758 mL
20 mM 0.1643 mL 0.8214 mL 1.6427 mL 4.1068 mL
25 mM 0.1314 mL 0.6571 mL 1.3142 mL 3.2855 mL
30 mM 0.1095 mL 0.5476 mL 1.0952 mL 2.7379 mL
40 mM 0.0821 mL 0.4107 mL 0.8214 mL 2.0534 mL
50 mM 0.0657 mL 0.3285 mL 0.6571 mL 1.6427 mL
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MeOIstPyrd Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MeOIstPyrd2308548-54-9MDM-2/p53anticancerp53 activatorp53-MDM2 interactionskin cancerInhibitorinhibitorinhibit

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