Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside

Name: Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside
Brand: MedChemExpress
SKU: HY-113949
Rating: 4.5 (1 reviews)

Cat. No.: HY-113949 Purity: ≥96.0%: FAQs
Data Sheet SDS COA Handling Instructions

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Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, obtained from D-ribose, is an intermediate for the synthesis of riboside-containing arsenic compound.

For research use only. We do not sell to patients.

Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside Chemical Structure

CAS No. : 4099-85-8

Size	Price	Stock	Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 28	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 28	In-stock	Estimated Time of Arrival: December 31
Liquid
500 mg	USD 25	In-stock	Estimated Time of Arrival: December 31
1 g	USD 35	In-stock	Estimated Time of Arrival: December 31
5 g	USD 100	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside:

Methyl 2,3-O-Isopropylidene-β-L-ribofuranoside Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Methyl 2,3-O-Isopropylidene-β-D-ribofuranoside, obtained from D-ribose, is an intermediate for the synthesis of riboside-containing arsenic compound^[1].

Molecular Weight

204.22

Formula

C₉H₁₆O₅

CAS No.

4099-85-8

Appearance

Liquid (Density: 1.23±0.1 g/cm³)

Color

Colorless to light yellow

SMILES

OC[C@@H](O1)[C@@H](O2)[C@@H](OC2(C)C)[C@@H]1OC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (489.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	4.8967 mL	24.4834 mL	48.9668 mL
5 mM	0.9793 mL	4.8967 mL	9.7934 mL
10 mM	0.4897 mL	2.4483 mL	4.8967 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (12.24 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: ≥96.0%

Select Batch:

Data Sheet (275 KB) SDS (394 KB)

COA (254 KB) HNMR (239 KB)

Handling Instructions (2659 KB)

References

[1]. Gyepes, A., et al. Synthesis and chromatographic study of methyl-2,3-O-isopropylidene-5-dimethyl-arsinoyl-β-d-ribofuranoside and methyl-2,3-O-isopropylidene-5-deoxy-5-dimethyl-thioarsinoyl-β-d-ribofuranoside. Polyhedron, 27(12), 2655-2661.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	4.8967 mL	24.4834 mL	48.9668 mL	122.4170 mL
	5 mM	0.9793 mL	4.8967 mL	9.7934 mL	24.4834 mL
	10 mM	0.4897 mL	2.4483 mL	4.8967 mL	12.2417 mL
	15 mM	0.3264 mL	1.6322 mL	3.2645 mL	8.1611 mL
	20 mM	0.2448 mL	1.2242 mL	2.4483 mL	6.1209 mL
	25 mM	0.1959 mL	0.9793 mL	1.9587 mL	4.8967 mL
	30 mM	0.1632 mL	0.8161 mL	1.6322 mL	4.0806 mL
	40 mM	0.1224 mL	0.6121 mL	1.2242 mL	3.0604 mL
	50 mM	0.0979 mL	0.4897 mL	0.9793 mL	2.4483 mL
	60 mM	0.0816 mL	0.4081 mL	0.8161 mL	2.0403 mL
	80 mM	0.0612 mL	0.3060 mL	0.6121 mL	1.5302 mL
	100 mM	0.0490 mL	0.2448 mL	0.4897 mL	1.2242 mL