Methyl gypsogenin-3-O-glucuronide (Synonyms: Gypsogenin-3-O-(6-O-methyl)-glucoside)

Name: Methyl gypsogenin-3-O-glucuronide
Brand: MedChemExpress
SKU: HY-N1439
Rating: 4.5 (1 reviews)

Cat. No.: HY-N1439 Purity: 99.89%: FAQs
Data Sheet SDS COA Handling Instructions

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Methyl gypsogenin-3-O-glucuronide (Gypsogenin-3-O-(6-O-methyl)-glucoside) is a ubiquitous saponin precursor in plants of the genus Gypsophila.

For research use only. We do not sell to patients.

Methyl gypsogenin-3-O-glucuronide Chemical Structure

CAS No. : 96553-02-5

Size	Price	Stock	Quantity
5 mg	USD 70	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 120	In-stock	Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Methyl gypsogenin-3-O-glucuronide (Gypsogenin-3-O-(6-O-methyl)-glucoside) is a ubiquitous saponin precursor in plants of the genus Gypsophila^[1].

In Vitro

Treatment of suspended G. paniculata cells with Methyl gypsogenin-3-O-glucuronide (Gypsogenin-3-O-(6-O-methyl)-glucoside) 24 hours before administration of [14C]acetate results in a marked reduction in the incorporation of radioactivity into saponins and their precursors but not into sterols and steryl glucosides^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

660.83

Formula

C₃₇H₅₆O₁₀

CAS No.

96553-02-5

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](C(OC)=O)O1)O)O)[C@@H]1O[C@H]2CC[C@]3(C)[C@@]4([H])CC=C5[C@]6([H])CC(C)(C)CC[C@]6(C(O)=O)CC[C@](C)5[C@@](C)4CC[C@@]3([H])[C@]2(C)C=O

Structure Classification

Initial Source

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (151.32 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.5132 mL	7.5662 mL	15.1325 mL
5 mM	0.3026 mL	1.5132 mL	3.0265 mL
10 mM	0.1513 mL	0.7566 mL	1.5132 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (3.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (3.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (3.78 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.89%

Select Batch:

Data Sheet (273 KB) SDS (252 KB)

COA (252 KB) HNMR (292 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. MaxHenry, et al. Effect of gypsogenin 3,O-glucuronide pretreatment of Gypsophila paniculata and Saponaria officinalis cell suspension cultures on the activities of microsomal 2,3-oxidosqualene cycloartenol and amyrin cyclases. Volume 31, Issue 11, 1992, Pages 3855-3859.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.5132 mL	7.5662 mL	15.1325 mL	37.8312 mL
	5 mM	0.3026 mL	1.5132 mL	3.0265 mL	7.5662 mL
	10 mM	0.1513 mL	0.7566 mL	1.5132 mL	3.7831 mL
	15 mM	0.1009 mL	0.5044 mL	1.0088 mL	2.5221 mL
	20 mM	0.0757 mL	0.3783 mL	0.7566 mL	1.8916 mL
	25 mM	0.0605 mL	0.3026 mL	0.6053 mL	1.5132 mL
	30 mM	0.0504 mL	0.2522 mL	0.5044 mL	1.2610 mL
	40 mM	0.0378 mL	0.1892 mL	0.3783 mL	0.9458 mL
	50 mM	0.0303 mL	0.1513 mL	0.3026 mL	0.7566 mL
	60 mM	0.0252 mL	0.1261 mL	0.2522 mL	0.6305 mL
	80 mM	0.0189 mL	0.0946 mL	0.1892 mL	0.4729 mL
	100 mM	0.0151 mL	0.0757 mL	0.1513 mL	0.3783 mL

Methyl gypsogenin-3-O-glucuronide Related Classifications

Inflammation/Immunology

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Methyl gypsogenin-3-O-glucuronide96553-02-5Gypsogenin-3-O-(6-O-methyl)-glucosideOthersubiquitoussaponinprecursorInhibitorinhibitorinhibit

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Methyl gypsogenin-3-O-glucuronide (Synonyms: Gypsogenin-3-O-(6-O-methyl)-glucoside)

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Methyl gypsogenin-3-O-glucuronide Related Antibodies

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Complete Stock Solution Preparation Table

Methyl gypsogenin-3-O-glucuronide Related Classifications

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