2. Apoptosis
  3. MDM-2/p53
  4. MI-888

MI-888 is an orally active MDM2 inhibitor with a Ki of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity.

For research use only. We do not sell to patients.

MI-888 Chemical Structure

MI-888 Chemical Structure

CAS No. : 1303607-59-1

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MI-888 Related Antibodies

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Description

MI-888 is an orally active MDM2 inhibitor with a Ki of 0.44 nM. MI-888 can inhibit the MDM2-p53 interaction. MI-888 has favorable pharmacokinetic properties and anti-tumor activity[1].

Molecular Weight

548.48

Formula

C28H32Cl2FN3O3
CAS No.
SMILES

CC(C)(C)C[C@H]1[C@]2(C3=CC=C(Cl)C=C3NC2=O)[C@@H](C4=C(C(Cl)=CC=C4)F)[C@@H](N1)C(N[C@H]5C[C@@](O)(C5)C)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MI-888 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MI-8881303607-59-1MI888MI 888MDM-2/p53acute leukemia xenograft modelSJSA-1 xenograft modelInhibitorinhibitorinhibit

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