MitoBloCK-11

Cat. No.: HY-125036 Purity: 99.28%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

MitoBloCK-11 is a new small molecule with a protein-binding target, Seo1. MitoBloCK-11 plays an important role in the delivery of PINK1 pathway. MitoBloCK-11 can be used in the study of autosomal recessive Parkinson's disease.

For research use only. We do not sell to patients.

MitoBloCK-11 Chemical Structure

CAS No. : 413606-16-3

Size	Price	Stock	Quantity
1 mg	USD 130	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 300	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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This product is a controlled substance and not for sale in your territory.

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Purity & Documentation
References
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Description

Molecular Weight

434.26

Formula

C₁₇H₁₂BrN₃O₄S

CAS No.

413606-16-3

Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(N/N=C/C1=CC=C([N+]([O-])=O)S1)COC2=C3C=CC=CC3=C(Br)C=C2

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (287.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3028 mL	11.5138 mL	23.0277 mL
5 mM	0.4606 mL	2.3028 mL	4.6055 mL
10 mM	0.2303 mL	1.1514 mL	2.3028 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.28%

Select Batch:

Data Sheet (273 KB) SDS (393 KB)

COA (246 KB) HNMR (281 KB) LCMS (86 KB)

Handling Instructions (2659 KB)

References

[1]. Conti Michael, et al. Small Molecule Probes of Mitochondrial Translocases Elucidate PINK1 Trafficking in PINK1/Parkin Regulated Mitophagy.2018.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3028 mL	11.5138 mL	23.0277 mL	57.5692 mL
	5 mM	0.4606 mL	2.3028 mL	4.6055 mL	11.5138 mL
	10 mM	0.2303 mL	1.1514 mL	2.3028 mL	5.7569 mL
	15 mM	0.1535 mL	0.7676 mL	1.5352 mL	3.8379 mL
	20 mM	0.1151 mL	0.5757 mL	1.1514 mL	2.8785 mL
	25 mM	0.0921 mL	0.4606 mL	0.9211 mL	2.3028 mL
	30 mM	0.0768 mL	0.3838 mL	0.7676 mL	1.9190 mL
	40 mM	0.0576 mL	0.2878 mL	0.5757 mL	1.4392 mL
	50 mM	0.0461 mL	0.2303 mL	0.4606 mL	1.1514 mL
	60 mM	0.0384 mL	0.1919 mL	0.3838 mL	0.9595 mL
	80 mM	0.0288 mL	0.1439 mL	0.2878 mL	0.7196 mL
	100 mM	0.0230 mL	0.1151 mL	0.2303 mL	0.5757 mL

MitoBloCK-11 Related Classifications

Neurological Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitoBloCK-11413606-16-3MitoBloCK11MitoBloCK 11PINK1/ParkinmitochondriaParkinson’s diseaseHeLa cellsInhibitorinhibitorinhibit

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