2. Immunology/Inflammation NF-κB Metabolic Enzyme/Protease
  3. Reactive Oxygen Species
  4. MitoTEMPOL

MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2-to H2O2.

For research use only. We do not sell to patients.

MitoTEMPOL Chemical Structure

MitoTEMPOL Chemical Structure

CAS No. : 1101113-39-6

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5 mg USD 180 In-stock
10 mg USD 290 In-stock
25 mg USD 580 In-stock
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Based on 1 publication(s) in Google Scholar

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Description

MitoTEMPOL is a a mitochondria-targeted nitroxide that reduces mitochondrial O2-to H2O2[1].

Molecular Weight

583.56

Formula

C32H42BrNO2P*
CAS No.
Appearance

Oil

Color

Brown to reddish brown

SMILES

[O]N1C(C)(CC(CC1(C)C)OCCCCC[P+](C2=CC=CC=C2)(C3=CC=CC=C3)C4=CC=CC=C4)C.[Br-]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvent & Solubility
In Vitro: 

DMF : 50 mg/mL (85.68 mM; Need ultrasonic and warming)

Ethanol : 50 mg/mL (85.68 mM; Need ultrasonic and warming)

DMSO : 50 mg/mL (85.68 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7136 mL 8.5681 mL 17.1362 mL
5 mM 0.3427 mL 1.7136 mL 3.4272 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

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Volume (start)

V1

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Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 98.00%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF / Ethanol / DMSO 1 mM 1.7136 mL 8.5681 mL 17.1362 mL 42.8405 mL
5 mM 0.3427 mL 1.7136 mL 3.4272 mL 8.5681 mL
10 mM 0.1714 mL 0.8568 mL 1.7136 mL 4.2840 mL
15 mM 0.1142 mL 0.5712 mL 1.1424 mL 2.8560 mL
20 mM 0.0857 mL 0.4284 mL 0.8568 mL 2.1420 mL
25 mM 0.0685 mL 0.3427 mL 0.6854 mL 1.7136 mL
30 mM 0.0571 mL 0.2856 mL 0.5712 mL 1.4280 mL
40 mM 0.0428 mL 0.2142 mL 0.4284 mL 1.0710 mL
50 mM 0.0343 mL 0.1714 mL 0.3427 mL 0.8568 mL
60 mM 0.0286 mL 0.1428 mL 0.2856 mL 0.7140 mL
80 mM 0.0214 mL 0.1071 mL 0.2142 mL 0.5355 mL
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MitoTEMPOL Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MitoTEMPOL1101113-39-6Reactive Oxygen Speciesmitochondria-targeted nitroxidereactive oxygen speciesInhibitorinhibitorinhibit

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