2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. MK-8189

MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia.

For research use only. We do not sell to patients.

MK-8189 Chemical Structure

MK-8189 Chemical Structure

CAS No. : 1424371-93-6

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1 mg USD 140 In-stock
5 mg USD 350 In-stock
10 mg USD 600 In-stock
25 mg USD 1250 In-stock
50 mg USD 1950 In-stock
100 mg USD 3200 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

MK-8189 Related Antibodies

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  • Biological Activity

  • Purity & Documentation

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Description

MK-8189 is a potent, orally active and selective PDE10A inhibitor with a Ki value of 29 pM. MK-8189 can be used in research of schizophrenia[1].

IC50 & Target[1]

PDE10A

29 pM (Ki)

In Vivo

MK-8189 (0.25-0.75 mg/kg; po) attenuates rats' locomotor activity in a dose-dependent manner[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar-Hannover rats[1]
Dosage: 0.25, 0.5, and 0.75 mg/kg
Administration: Oral administration
Result: Improved identification ability relative to the vector handling animal.
Clinical Trial
Molecular Weight

382.48

Formula

C19H22N6OS
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

CC(S1)=NN=C1CNC2=CC(OC[C@@H]3[C@@H](C4=CC=C(C=N4)C)C3)=NC(C)=N2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (326.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6145 mL 13.0726 mL 26.1452 mL
5 mM 0.5229 mL 2.6145 mL 5.2290 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.6145 mL 13.0726 mL 26.1452 mL 65.3629 mL
5 mM 0.5229 mL 2.6145 mL 5.2290 mL 13.0726 mL
10 mM 0.2615 mL 1.3073 mL 2.6145 mL 6.5363 mL
15 mM 0.1743 mL 0.8715 mL 1.7430 mL 4.3575 mL
20 mM 0.1307 mL 0.6536 mL 1.3073 mL 3.2681 mL
25 mM 0.1046 mL 0.5229 mL 1.0458 mL 2.6145 mL
30 mM 0.0872 mL 0.4358 mL 0.8715 mL 2.1788 mL
40 mM 0.0654 mL 0.3268 mL 0.6536 mL 1.6341 mL
50 mM 0.0523 mL 0.2615 mL 0.5229 mL 1.3073 mL
60 mM 0.0436 mL 0.2179 mL 0.4358 mL 1.0894 mL
80 mM 0.0327 mL 0.1634 mL 0.3268 mL 0.8170 mL
100 mM 0.0261 mL 0.1307 mL 0.2615 mL 0.6536 mL
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MK-8189 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MK-81891424371-93-6MK8189MK 8189Phosphodiesterase (PDE)schizophreniaidentification abilityInhibitorinhibitorinhibit

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