MM41

Cat. No.: HY-16967 Purity: 99.92%: FAQs
Data Sheet SDS COA Handling Instructions

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MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC₅₀ value of <10 nM.

For research use only. We do not sell to patients.

MM41 Chemical Structure

CAS No. : 1429028-96-5

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 347	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 347	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 380	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 620	In-stock	Estimated Time of Arrival: December 31
50 mg	USD 850	In-stock	Estimated Time of Arrival: December 31
100 mg	USD 1100	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Description

MM41 is a potent stabilizer of human telomeric and gene promoter DNA quadruplexes. MM41 is potently against the MIA PaCa-2 pancreatic cancer cell line with IC₅₀ value of <10 nM^[1].

Cellular Effect

Cell Line	Type	Value	Description	References
786-0	IC₅₀	0.32 μM Compound: 3d	Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human 786-0 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
A549	IC₅₀	< 0.01 μM Compound: 3d	Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human A549 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
A549	IC₅₀	19 nM Compound: MM41	Growth inhibition of human A549 cells after 96 hrs by SRB assay Growth inhibition of human A549 cells after 96 hrs by SRB assay	[PMID: 29356532]
MCF7	IC₅₀	0.07 μM Compound: 3d	Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MCF7 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
MCF7	IC₅₀	70 nM Compound: MM41	Growth inhibition of human MCF7 cells after 96 hrs by SRB assay Growth inhibition of human MCF7 cells after 96 hrs by SRB assay	[PMID: 29356532]
MIA PaCa-2	IC₅₀	0.01 μM Compound: 3d	Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human MIAPaCa2 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
MIA PaCa-2	IC₅₀	11 nM Compound: MM41	Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay Growth inhibition of human MIAPaCa2 cells after 96 hrs by SRB assay	[PMID: 29356532]
PANC-1	IC₅₀	0.003 μM Compound: 2a	Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay Cytotoxicity against human PANC1 cells after 96 hrs by SRB assay	[PMID: 23769166]
PANC-1	IC₅₀	3 nM Compound: MM41	Growth inhibition of human PANC1 cells after 96 hrs by SRB assay Growth inhibition of human PANC1 cells after 96 hrs by SRB assay	[PMID: 29356532]
RCC4	IC₅₀	0.56 μM Compound: 3d	Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human RCC4 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
WI-38	IC₅₀	0.23 μM Compound: 3d	Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay Cytotoxicity against human WI38 cells assessed as growth inhibition after 96 hrs by SRB assay	[PMID: 23514618]
WI-38	IC₅₀	230 nM Compound: MM41	Growth inhibition of human WI38 cells after 96 hrs by SRB assay Growth inhibition of human WI38 cells after 96 hrs by SRB assay	[PMID: 29356532]

Molecular Weight

831.06

Formula

C₄₄H₆₆N₁₀O₆

CAS No.

1429028-96-5

Appearance

Solid

Color

Blue to purple

SMILES

O=C1C2=CC(NCCCN3CCN(CC3)C)=C4C(N(CCCN5CCOCC5)C(C6=CC(NCCCN7CCN(CC7)C)=C(C2=C64)C(N1CCCN8CCOCC8)=O)=O)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 33.33 mg/mL (40.11 mM; ultrasonic and adjust pH to 8 with HCl; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	1.2033 mL	6.0164 mL	12.0328 mL
5 mM	0.2407 mL	1.2033 mL	2.4066 mL
10 mM	0.1203 mL	0.6016 mL	1.2033 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.92%

Select Batch:

Data Sheet (269 KB) SDS (251 KB)

COA (249 KB) HNMR (294 KB) LCMS (264 KB)

Handling Instructions (2659 KB)

References

[1]. Marialuisa Micco, et al. Structure-based design and evaluation of naphthalene diimide G-quadruplex ligands as telomere targeting agents in pancreatic cancer cells. J Med Chem [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	1.2033 mL	6.0164 mL	12.0328 mL	30.0821 mL
	5 mM	0.2407 mL	1.2033 mL	2.4066 mL	6.0164 mL
	10 mM	0.1203 mL	0.6016 mL	1.2033 mL	3.0082 mL
	15 mM	0.0802 mL	0.4011 mL	0.8022 mL	2.0055 mL
	20 mM	0.0602 mL	0.3008 mL	0.6016 mL	1.5041 mL
	25 mM	0.0481 mL	0.2407 mL	0.4813 mL	1.2033 mL
	30 mM	0.0401 mL	0.2005 mL	0.4011 mL	1.0027 mL
	40 mM	0.0301 mL	0.1504 mL	0.3008 mL	0.7521 mL

MM41 Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MM411429028-96-5MM 41MM-41G-quadruplexPaCa-2pancreatic cancerA549RCC4,786-0cancer,stabilizerInhibitorinhibitorinhibit

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MM41

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Complete Stock Solution Preparation Table

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