2. JAK/STAT Signaling Cell Cycle/DNA Damage Protein Tyrosine Kinase/RTK
  3. EGFR CDK VEGFR
  4. Multi-target kinase inhibitor 2

Multi-target kinase inhibitor 2 

Cat. No.: HY-149636 Purity: 99.82%
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Multi-target kinase inhibitor 2 (compound 5K) is a multi-targeted kinase inhibitor, and exhibits activity against EGFR, Her2, VEGFR2, and CDK2 enzymes, with IC50 values ranging from 40 to 204 nM. Multi-target kinase inhibitor 2 shows cytotoxic effects were observed against HepG2, HeLa , MDA-MB-231 and MCF-7, with IC50 of 41, 57, 51 and 59 μM. Multi-target kinase inhibitor 2 induces cell cycle arrest and apoptosis in HepG2 cells.

For research use only. We do not sell to patients.

Multi-target kinase inhibitor 2 Chemical Structure

Multi-target kinase inhibitor 2 Chemical Structure

Size Price Stock Quantity
5 mg USD 120 In-stock
10 mg USD 190 In-stock
25 mg USD 360 In-stock
50 mg USD 580 In-stock
100 mg USD 930 In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

Multi-target kinase inhibitor 2 Related Antibodies

Top Publications Citing Use of Products

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

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CDK1 CDK2 CDK3 CDK4 CDK5 CDK6 CDK7 CDK8 CDK9 CDK11 CDK12 CDK13 CDK14 CDK16 CDK19 CDC CLK Pho85

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VEGFR1/Flt-1 VEGFR2/KDR/Flk-1 VEGFR3/Flt-4

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Description

Multi-target kinase inhibitor 2 (compound 5K) is a multi-targeted kinase inhibitor, and exhibits activity against EGFR, Her2, VEGFR2, and CDK2 enzymes, with IC50 values ranging from 40 to 204 nM. Multi-target kinase inhibitor 2 shows cytotoxic effects were observed against HepG2, HeLa , MDA-MB-231 and MCF-7, with IC50 of 41, 57, 51 and 59 μM. Multi-target kinase inhibitor 2 induces cell cycle arrest and apoptosis in HepG2 cells.

Molecular Weight

425.27

Formula

C20H14Cl2N6O
Appearance

Solid

Color

White to off-white

SMILES

O=C(N/N=C/C1=CC(Cl)=C(Cl)C=C1)C2=CC=C(C=C2)NC3=NC=NC4=C3C=CN4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (47.03 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3514 mL 11.7572 mL 23.5145 mL
5 mM 0.4703 mL 2.3514 mL 4.7029 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3514 mL 11.7572 mL 23.5145 mL 58.7862 mL
5 mM 0.4703 mL 2.3514 mL 4.7029 mL 11.7572 mL
10 mM 0.2351 mL 1.1757 mL 2.3514 mL 5.8786 mL
15 mM 0.1568 mL 0.7838 mL 1.5676 mL 3.9191 mL
20 mM 0.1176 mL 0.5879 mL 1.1757 mL 2.9393 mL
25 mM 0.0941 mL 0.4703 mL 0.9406 mL 2.3514 mL
30 mM 0.0784 mL 0.3919 mL 0.7838 mL 1.9595 mL
40 mM 0.0588 mL 0.2939 mL 0.5879 mL 1.4697 mL
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Multi-target kinase inhibitor 2 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Multi-target kinase inhibitor 2EGFRCDKVEGFREpidermal growth factor receptorErbB-1HER1Cyclin dependent kinaseVascular endothelial growth factor receptorPyrrolo[2,3-d]pyrimidineapoptosis inducertyrosine kinase inhibitormultiple kinase inhibitorInhibitorinhibitorinhibit

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