2. Apoptosis Anti-infection Metabolic Enzyme/Protease
  3. Dengue virus Apoptosis Bacterial Fungal Antibiotic Endogenous Metabolite Flavivirus
  4. Mycophenolic acid sodium

Mycophenolic acid sodium  (Synonyms: Mycophenolate sodium)

Cat. No.: HY-B0421A Purity: 99.98%
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Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects.

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Mycophenolic acid sodium Chemical Structure

Mycophenolic acid sodium Chemical Structure

CAS No. : 37415-62-6

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Based on 7 publication(s) in Google Scholar

Other Forms of Mycophenolic acid sodium:

Mycophenolic acid sodium Related Antibodies

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Description

Mycophenolic acid sodium is a potent uncompetitive inosine monophosphate dehydrogenase (IMPDH) inhibitor with an EC50 of 0.24 μM. Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza. Mycophenolic acid sodium is an immunosuppressive agent. Antiangiogenic and antitumor effects[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Mycophenolic acid sodium demonstrates antiviral effects against a wide range of RNA viruses including influenza, dengue virus, Zika virus, rotavirus, CCHFV, and hantavirus[1].
IMPDH is the rate-limiting enzyme in the de novo synthesis of guanosine nucleotides[2].
Mycophenolic acid (0.01-1 μM; 72 hours) sodium exhibits preferential antiproliferative activity against the endothelial cells and fibroblasts. Endothelial cells are most sensitive cells to Mycophenolic acid treatment with an IC50 <500 nM for antimitotic effects[2].
Fibroblasts are also prone to Mycophenolic acid-induced cell cycle inhibition but exhibit a higher IC50 (<1 μM) compared with endothelial cells. The two human tumor cell lines A549 non-small cell lung cancer cells and PC3 prostate cancer cells show intermediate sensitivity with an IC50 >1 μM. U87 glioblastoma cells are resistant against Mycophenolic acid sodium treatment up to 1 μM[2].
Mycophenolic acid (0.05-2 μM; 18 hours) sodium exhibits a dose-dependent down-regulation of HDAC2 and MYC, whereas up-regulates NDRG1[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Mycophenolic acid sodium Related Antibodies

Cell Proliferation Assay[2]

Cell Line: Primary isolated human dermal microvascular endothelial cells (HDMVEC) , fibroblasts, U87 glioblastoma cells, PC3 prostate cancer cells, A549 non-small cell lung cancer cells.
Concentration: 0.01, 0.1, 1 μM
Incubation Time: 72 hours
Result: Exhibited preferential antiproliferative activity against HDMVEC and fibroblasts. Whereas U87 glioblastoma cells were resistant to treatment, A549 non-small cell lung cancer and PC3 prostate cancer cells showed intermediate sensitivity.

Western Blot Analysis[2]

Cell Line: HDMVEC
Concentration: 0, 0.05, 0.1, 0.5, 1, and 2 μM
Incubation Time: 18 hours
Result: Showed a dose-dependent regulation of HDAC2, MYC, and NDRG1.
In Vivo

Mycophenolic acid (120 mg/kg; oral gavage; b.i.d.) sodium exerts its antitumor effects via modulation of the tumor microenvironment, U87 tumor growth is markedly inhibited in vivo in BALB/c nude mice[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Athymic 8-week-old, 20 g BALB/c nu/nu mice bearing Mycophenolic acid-resistant human U87 tumor model[2]
Dosage: 120 mg/kg MMF (the morpholinoethyl ester prodrug of Mycophenolic acid)
Administration: Oral gavage; b.i.d.
Result: MMF (the morpholinoethyl ester prodrug of Mycophenolic acid) significantly inhibited tumor growth (∼70% after day 14 after tumor implantation) in MMF-treated versus control mice.
Microvessel density (CD31 staining) and pericyte coverage determined by α-smooth muscle actin staining were markedly reduced in MMF-treated versus control tumors (44% and 78%, respectively).
Clinical Trial
Molecular Weight

342.32

Formula

C17H19NaO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O[Na])CC/C(C)=C/CC1=C(O)C2=C(COC2=O)C(C)=C1OC
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 175 mg/mL (511.22 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 175 mg/mL (511.22 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.9212 mL 14.6062 mL 29.2124 mL
5 mM 0.5842 mL 2.9212 mL 5.8425 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.98%

SDS (701 KB)

COA (247 KB) HNMR (240 KB) LCMS (94 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 2.9212 mL 14.6062 mL 29.2124 mL 73.0311 mL
5 mM 0.5842 mL 2.9212 mL 5.8425 mL 14.6062 mL
10 mM 0.2921 mL 1.4606 mL 2.9212 mL 7.3031 mL
15 mM 0.1947 mL 0.9737 mL 1.9475 mL 4.8687 mL
20 mM 0.1461 mL 0.7303 mL 1.4606 mL 3.6516 mL
25 mM 0.1168 mL 0.5842 mL 1.1685 mL 2.9212 mL
30 mM 0.0974 mL 0.4869 mL 0.9737 mL 2.4344 mL
40 mM 0.0730 mL 0.3652 mL 0.7303 mL 1.8258 mL
50 mM 0.0584 mL 0.2921 mL 0.5842 mL 1.4606 mL
60 mM 0.0487 mL 0.2434 mL 0.4869 mL 1.2172 mL
80 mM 0.0365 mL 0.1826 mL 0.3652 mL 0.9129 mL
100 mM 0.0292 mL 0.1461 mL 0.2921 mL 0.7303 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Mycophenolic acid sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Mycophenolic acid37415-62-6MycophenolateDengue virusApoptosisBacterialFungalAntibioticEndogenous MetaboliteFlavivirusDENVinosinemonophosphatedehydrogenaseIMPDHantiviralRNAvirusesinfluenzaimmunosuppressiveAntiangiogenicantitumorInhibitorinhibitorinhibit

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