Mycro2 

Mycro2 is an inhibitor of c-Myc/Max dimer and DNA binding, with an IC₅₀ value of 23 μM for the inhibition of Myc/Max DNA binding activity. Mycro2 can inhibit c-myc-dependent cell proliferation, gene transcription and oncogenic transformation^[1].

Mycro2 (10 or 20 μM, 7 days) can inhibit the proliferation of C-Myc-dependent cell lines U-2OS, MCF-7, Raji and NIH/3T3, but does not inhibit the proliferation of C-Myc-independent cancer cell line PC-12. Mycro2 significantly inhibits c-myc-induced gene transcription at 10 μM and selectively reduces unanchored growth of c-myc-transformed Rat1a cells at 20 μM^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

408.42

C₁₇H₁₁F₃N₄OS₂

314049-21-3

Solid

Light yellow to yellow

O=C(C1=NN2C(C(F)(F)F)=CC(C3=CC=CS3)=NC2=C1)NCC4=CC=CS4

Room temperature in continental US; may vary elsewhere.

• [1]. Kiessling A, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.  [Content Brief]

  [2]. Anke Kiessling, et al. Selective inhibition of c-Myc/Max dimerization and DNA binding by small molecules. Chem Biol. 2006 Jul;13(7):745-51.