2. Metabolic Enzyme/Protease
  3. Endogenous Metabolite
  4. N-Acetyl-D-mannosamine

N-Acetyl-D-mannosamine  (Synonyms: N-Acetylmannosamine; ManNAc)

Cat. No.: HY-128850 Purity: ≥98.0%
SDS COA Handling Instructions Technical Support

N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders.

For research use only. We do not sell to patients.

N-Acetyl-D-mannosamine Chemical Structure

N-Acetyl-D-mannosamine Chemical Structure

CAS No. : 3615-17-6

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
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10 mM * 1 mL in Water In-stock
Solid
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Based on 1 publication(s) in Google Scholar

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N-Acetyl-D-mannosamine Related Antibodies

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Description

N-Acetyl-D-mannosamine (ManNAc) is an oral active sialic acid precursor that can prevent hypertension by increasing sialylation of IgG, making it a promising candidate for cardiovascular disease research. Additionally, N-Acetyl-D-mannosamine can activate hypocretin (HCRT) gene expression in orexin neurons and improve neurodegeneration caused by aging, offering potential avenues for research in neurological disorders[1][2][3][4][5].

IC50 & Target

Human Endogenous Metabolite

 

In Vivo

N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 1%, p.o., once daily for 16 weeks) can prevent obesity-induced hypertension in a high-fat diet-induced hypertensive mouse model by increasing the sialylation level of IgG glycans[3].
N-Acetyl-D-mannosamine (administered orally in drinking water at a dose of 2 g/kg, 4-6 mL per day, for 12 weeks) can reverse the reduction in sialylation in the kidneys and muscles of a GNE myopathy C57BL/6J mouse model with the knock-in (Gne p.M712T) mutation[4].
N-Acetyl-D-mannosamine (administered orally in drinking water at a concentration of 0.5%, ad libitum, for 8 weeks) improves synaptic transmission and Long-Term Potentiation (LTP) in 6-month-old and 14-month-old SAMR1 mice[4]。

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: High-fat diet-induced hypertension C57BL/6 mice model[2]
Dosage: Dissolved in drinking water at a concentration of 1%
Administration: Oral gavage (p.o.), once daily for 16 weeks
Result: Inhibited high-fat diet-induced weight gain and increased the sialylation of IgG glycans.
Animal Model: Knock-in C57BL/6J mice model (Gne p.M712T) of GNE myopathy
Dosage: 1 or 2 g/kg
Administration: Administered via drinking water (4-6 mL daily), once daily for 12 weeks
Result: Showed a significant decrease of proteinuria after only one week on the treatment (2 g/kg)
Molecular Weight

221.21

Formula

C8H15NO6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC[C@@H](O)[C@@H](O)[C@H](O)[C@@H](C=O)NC(C)=O
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (565.07 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.5206 mL 22.6030 mL 45.2059 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 25 mg/mL (113.01 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

SDS (393 KB)

COA (249 KB) HNMR (262 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 4.5206 mL 22.6030 mL 45.2059 mL 113.0148 mL
5 mM 0.9041 mL 4.5206 mL 9.0412 mL 22.6030 mL
10 mM 0.4521 mL 2.2603 mL 4.5206 mL 11.3015 mL
15 mM 0.3014 mL 1.5069 mL 3.0137 mL 7.5343 mL
20 mM 0.2260 mL 1.1301 mL 2.2603 mL 5.6507 mL
25 mM 0.1808 mL 0.9041 mL 1.8082 mL 4.5206 mL
30 mM 0.1507 mL 0.7534 mL 1.5069 mL 3.7672 mL
40 mM 0.1130 mL 0.5651 mL 1.1301 mL 2.8254 mL
50 mM 0.0904 mL 0.4521 mL 0.9041 mL 2.2603 mL
60 mM 0.0753 mL 0.3767 mL 0.7534 mL 1.8836 mL
80 mM 0.0565 mL 0.2825 mL 0.5651 mL 1.4127 mL
100 mM 0.0452 mL 0.2260 mL 0.4521 mL 1.1301 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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N-Acetyl-D-mannosamine Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-D-mannosamine3615-17-6N-Acetylmannosamine ManNAcEndogenous MetaboliteHigh-fat diet-induced hypertension mice modelKnock-in mice model (Gne p.M712T) of GNE myopathy,Inhibitorinhibitorinhibit

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