N-Acetyl-L-methionine-d₃ (Synonyms: N-Acetylmethionine-d₃)

Cat. No.: HY-W012499S Purity: 99.87%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Acetyl-L-methionine-d₃ is the deuterium labeled N-Acetyl-L-methionine. N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development[1].

For research use only. We do not sell to patients.

N-Acetyl-L-methionine-d<sub>3</sub> Chemical Structure

N-Acetyl-L-methionine-d₃ Chemical Structure

Size	Price	Stock	Quantity
1 mg	USD 160	In-stock	Estimated Time of Arrival: December 31
5 mg	USD 400	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 540	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Other Forms of N-Acetyl-L-methionine-d₃:

N-Acetyl-L-methionine Get quote

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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

194.27

Formula

C₇H₁₀D₃NO₃S

Appearance

Solid

Color

White to off-white

SMILES

CC(N[C@H](C(O)=O)CCSC([2H])([2H])[2H])=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (514.75 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.1475 mL	25.7374 mL	51.4748 mL
5 mM	1.0295 mL	5.1475 mL	10.2950 mL
10 mM	0.5147 mL	2.5737 mL	5.1475 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.87%

Select Batch:

Data Sheet (271 KB) SDS (251 KB)

COA (248 KB) LCMS (90 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Ball RO, et al. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136(6 Suppl):1682S-1693S. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.1475 mL	25.7374 mL	51.4748 mL	128.6869 mL
	5 mM	1.0295 mL	5.1475 mL	10.2950 mL	25.7374 mL
	10 mM	0.5147 mL	2.5737 mL	5.1475 mL	12.8687 mL
	15 mM	0.3432 mL	1.7158 mL	3.4317 mL	8.5791 mL
	20 mM	0.2574 mL	1.2869 mL	2.5737 mL	6.4343 mL
	25 mM	0.2059 mL	1.0295 mL	2.0590 mL	5.1475 mL
	30 mM	0.1716 mL	0.8579 mL	1.7158 mL	4.2896 mL
	40 mM	0.1287 mL	0.6434 mL	1.2869 mL	3.2172 mL
	50 mM	0.1029 mL	0.5147 mL	1.0295 mL	2.5737 mL
	60 mM	0.0858 mL	0.4290 mL	0.8579 mL	2.1448 mL
	80 mM	0.0643 mL	0.3217 mL	0.6434 mL	1.6086 mL
	100 mM	0.0515 mL	0.2574 mL	0.5147 mL	1.2869 mL

N-Acetyl-L-methionine-d₃ Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-L-methionine-d₃N-Acetylmethionine-d₃Isotope-Labeled CompoundsEndogenous MetaboliteInhibitorinhibitorinhibit

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N-Acetyl-L-methionine-d3 (Synonyms: N-Acetylmethionine-d3)

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