N-Acetyl-L-methionine (Synonyms: N-Acetylmethionine)

Name: N-Acetyl-L-methionine
Brand: MedChemExpress
SKU: HY-W012499
Rating: 4.5 (1 reviews)

Cat. No.: HY-W012499 Purity: 99.46%: FAQs
Data Sheet SDS COA Handling Instructions

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N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development.

For research use only. We do not sell to patients.

N-Acetyl-L-methionine Chemical Structure

CAS No. : 65-82-7

Size	Price	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 55	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 55	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
200 mg		Get quote
500 mg		Get quote

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Acetyl-L-methionine:

N-Acetyl-L-methionine-d₃ Get quote
N-Acetyl-DL-methionine Get quote
N-Acetyl-L-methionine (Standard) Get quote

1 Publications Citing Use of MCE N-Acetyl-L-methionine

•Laurea Magistrale in Biomedical Engineering, Politecnico di Milano. 2019 Jun.

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Description

N-Acetyl-L-methionine, a human metabolite, is nutritionally and metabolically equivalent to L-methionine. L-methionine is an indispensable amino acid required for normal growth and development^[1].

IC₅₀ & Target

Human Endogenous Metabolite

Molecular Weight

191.25

Formula

C₇H₁₃NO₃S

CAS No.

65-82-7

Appearance

Solid

Color

White to off-white

SMILES

CSCC[C@H](NC(C)=O)C(O)=O

Structure Classification

Amino acids

Initial Source

Microorganisms

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 100 mg/mL (522.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	5.2288 mL	26.1438 mL	52.2876 mL
5 mM	1.0458 mL	5.2288 mL	10.4575 mL
10 mM	0.5229 mL	2.6144 mL	5.2288 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (13.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (13.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (13.07 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Please enter your animal formula composition:

DMSO +

Tween-80 +

Saline

Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.

The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).

Calculation results:

Working solution concentration: mg/mL

Method for preparing stock solution: mg drug dissolved in μL DMSO (Stock solution concentration: mg/mL).

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).

Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.

If the continuous dosing period exceeds half a month, please choose this protocol carefully.

Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.

Purity & Documentation

Purity: 99.46%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (247 KB) LCMS (89 KB)

Handling Instructions (2659 KB)

References

[1]. Ball RO, et al. The in vivo sparing of methionine by cysteine in sulfur amino acid requirements in animal models and adult humans. J Nutr. 2006 Jun;136(6 Suppl):1682S-1693S. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	5.2288 mL	26.1438 mL	52.2876 mL	130.7190 mL
	5 mM	1.0458 mL	5.2288 mL	10.4575 mL	26.1438 mL
	10 mM	0.5229 mL	2.6144 mL	5.2288 mL	13.0719 mL
	15 mM	0.3486 mL	1.7429 mL	3.4858 mL	8.7146 mL
	20 mM	0.2614 mL	1.3072 mL	2.6144 mL	6.5359 mL
	25 mM	0.2092 mL	1.0458 mL	2.0915 mL	5.2288 mL
	30 mM	0.1743 mL	0.8715 mL	1.7429 mL	4.3573 mL
	40 mM	0.1307 mL	0.6536 mL	1.3072 mL	3.2680 mL
	50 mM	0.1046 mL	0.5229 mL	1.0458 mL	2.6144 mL
	60 mM	0.0871 mL	0.4357 mL	0.8715 mL	2.1786 mL
	80 mM	0.0654 mL	0.3268 mL	0.6536 mL	1.6340 mL
	100 mM	0.0523 mL	0.2614 mL	0.5229 mL	1.3072 mL

N-Acetyl-L-methionine Related Classifications

Metabolic Disease

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Acetyl-L-methionine65-82-7N-AcetylmethionineEndogenous MetaboliteInhibitorinhibitorinhibit

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N-Acetyl-L-methionine (Synonyms: N-Acetylmethionine)

Customer Review

Other Forms of N-Acetyl-L-methionine:

N-Acetyl-L-methionine Related Antibodies

1 Publications Citing Use of MCE N-Acetyl-L-methionine

Featured Recommendations

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Biological Activity

Purity & Documentation

References

Customer Review

Molarity Calculator

Dilution Calculator

Complete Stock Solution Preparation Table

N-Acetyl-L-methionine Related Classifications

Keywords:

Your Recently Viewed Products:

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