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  4. N-Nitrosodibutylamine

N-Nitrosodibutylamine  (Synonyms: N-Nitroso-di-n-butylamine)

Cat. No.: HY-131113 Purity: 99.96%
SDS COA Handling Instructions

Molarity Calculator

N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water.

For research use only. We do not sell to patients.

N-Nitrosodibutylamine Chemical Structure

N-Nitrosodibutylamine Chemical Structure

CAS No. : 924-16-3

Size Price Stock Quantity
100 mg USD 35 In-stock
250 mg USD 70 In-stock
500 mg USD 112 In-stock
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5 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of N-Nitrosodibutylamine:

N-Nitrosodibutylamine Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE N-Nitrosodibutylamine

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

N-Nitrosodibutylamine (N-Nitroso-di-n-butylamine) is a nitrosamine enriched in the drinking water[1].

Molecular Weight

158.24

Formula

C8H18N2O
CAS No.
Appearance

Liquid (Density: 0.9009 g/cm3)

Color

Light yellow to yellow

SMILES

CCCCN(CCCC)N=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (631.95 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 6.3195 mL 31.5976 mL 63.1951 mL
5 mM 1.2639 mL 6.3195 mL 12.6390 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 6.25 mg/mL (39.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in Saline)

    Solubility: ≥ 6.25 mg/mL (39.50 mM); Clear solution

    This protocol yields a clear solution of ≥ 6.25 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (62.5 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.

    Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 99.96%

SDS (617 KB)

COA (241 KB) HNMR (215 KB) LCMS (264 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 6.3195 mL 31.5976 mL 63.1951 mL 157.9879 mL
5 mM 1.2639 mL 6.3195 mL 12.6390 mL 31.5976 mL
10 mM 0.6320 mL 3.1598 mL 6.3195 mL 15.7988 mL
15 mM 0.4213 mL 2.1065 mL 4.2130 mL 10.5325 mL
20 mM 0.3160 mL 1.5799 mL 3.1598 mL 7.8994 mL
25 mM 0.2528 mL 1.2639 mL 2.5278 mL 6.3195 mL
30 mM 0.2107 mL 1.0533 mL 2.1065 mL 5.2663 mL
40 mM 0.1580 mL 0.7899 mL 1.5799 mL 3.9497 mL
50 mM 0.1264 mL 0.6320 mL 1.2639 mL 3.1598 mL
60 mM 0.1053 mL 0.5266 mL 1.0533 mL 2.6331 mL
80 mM 0.0790 mL 0.3950 mL 0.7899 mL 1.9748 mL
100 mM 0.0632 mL 0.3160 mL 0.6320 mL 1.5799 mL
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N-Nitrosodibutylamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nitrosodibutylamine924-16-3N-Nitroso-di-n-butylamineOthersInhibitorinhibitorinhibit

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