2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. N-Nitrosodicyclohexylamine

N-Nitrosodicyclohexylamine  (Synonyms: NDCHA)

Cat. No.: HY-W653723 Purity: ≥99.0%
COA Handling Instructions

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N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein.

For research use only. We do not sell to patients.

N-Nitrosodicyclohexylamine Chemical Structure

N-Nitrosodicyclohexylamine Chemical Structure

CAS No. : 947-92-2

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25 mg USD 60 In-stock
50 mg USD 95 In-stock
100 mg USD 150 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of N-Nitrosodicyclohexylamine:

N-Nitrosodicyclohexylamine Related Antibodies

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  • Purity & Documentation

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Description

N-Nitrosodicyclohexylamine (NDCHA) is a N-nitrosocompound with anti-androgenic activities. N-Nitrosodicyclohexylamine shows the competitive binding to androgen receptor (AR) against 5α-dihydrotestosterone and decreased the level of AR protein[1].

Molecular Weight

210.32

Formula

C12H22N2O
CAS No.
Appearance

Solid

Color

White to light yellow

SMILES

O=NN(C1CCCCC1)C2CCCCC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 50 mg/mL (237.73 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 4.7547 mL 23.7733 mL 47.5466 mL
5 mM 0.9509 mL 4.7547 mL 9.5093 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 2.5 mg/mL (11.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: ≥99.0%

COA (249 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 4.7547 mL 23.7733 mL 47.5466 mL 118.8665 mL
5 mM 0.9509 mL 4.7547 mL 9.5093 mL 23.7733 mL
10 mM 0.4755 mL 2.3773 mL 4.7547 mL 11.8866 mL
15 mM 0.3170 mL 1.5849 mL 3.1698 mL 7.9244 mL
20 mM 0.2377 mL 1.1887 mL 2.3773 mL 5.9433 mL
25 mM 0.1902 mL 0.9509 mL 1.9019 mL 4.7547 mL
30 mM 0.1585 mL 0.7924 mL 1.5849 mL 3.9622 mL
40 mM 0.1189 mL 0.5943 mL 1.1887 mL 2.9717 mL
50 mM 0.0951 mL 0.4755 mL 0.9509 mL 2.3773 mL
60 mM 0.0792 mL 0.3962 mL 0.7924 mL 1.9811 mL
80 mM 0.0594 mL 0.2972 mL 0.5943 mL 1.4858 mL
100 mM 0.0475 mL 0.2377 mL 0.4755 mL 1.1887 mL
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N-Nitrosodicyclohexylamine Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

N-Nitrosodicyclohexylamine947-92-2NDCHAAndrogen ReceptorN-nitrosocompoundandrogen receptorα-dihydrotestosteroneInhibitorinhibitorinhibit

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