n-Octyl β-D-glucopyranoside

Name: n-Octyl β-D-glucopyranoside
Brand: MedChemExpress
SKU: HY-116285
Rating: 4.5 (1 reviews)

Cat. No.: HY-116285 Purity: ≥98.0%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

n-Octyl-β-d-glucopyranoside is a non-ionic detergent, it can be widely used in the research of biotechnical, biochemical applications, solubilization and crystallization of membrane proteins. n-Octyl-β-d-glucopyranoside can completely inhibit cavitation-induced cell lysis in vitro.

For research use only. We do not sell to patients.

n-Octyl β-D-glucopyranoside Chemical Structure

CAS No. : 29836-26-8

Size	Price	Stock	Quantity

Free Sample (0.1 - 0.5 mg)		Apply Now
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	USD 33	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	USD 33	In-stock	Estimated Time of Arrival: December 31
Solid
100 mg	USD 30	In-stock	Estimated Time of Arrival: December 31
500 mg	USD 50	In-stock	Estimated Time of Arrival: December 31
1 g	USD 70	In-stock	Estimated Time of Arrival: December 31
5 g	USD 120	In-stock	Estimated Time of Arrival: December 31
10 g		Get quote
50 g		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of n-Octyl β-D-glucopyranoside:

n-Octyl β-D-glucopyranoside-d₂₄ Get quote
1-O-n-Octyl-β-D-glucopyranoside-d₁₇ Get quote

1 Publications Citing Use of MCE n-Octyl β-D-glucopyranoside

•Autophagy. 2024 Jul 2. [Abstract]

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•Related Screening Libraries:

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Cellular Effect

Cell Line	Type	Value	Description	References
WI-38	EC₅₀	> 100 μM Compound: 2, BTB11967	Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Antiviral activity against BKV Gardner ATCC VR837 infected in human WI38 cells assessed as reduction in viral DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]
WI-38	CC₅₀	> 100 μM Compound: 2, BTB11967	Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay Cytotoxicity against human WI38 cells assessed as reduction in cellular DNA level preincubated for 2 hrs before viral infection measured after 7 days by real time PCR assay	[PMID: 17893158]

In Vitro

Suspensions of HL-60 cells are exposed to 1.057 MHz unfocused ultrasound for 5-15 s with various additions of alkyl glucopyranosides. 2 mM n-Octyl β-D-glucopyranoside (OGP) added to the medium resultes in 100% survival of the cells after 5 s exposure under conditions which produces 35%-100% cell lysis without the additive^[3].
Variation of the concentration of n-Octyl β-D-glucopyranoside for 0.5 MPa exposure produced increased cavitation and lysis at 1 mM relative to 0 mM, but decreased cavitation at 5 mM^[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

292.37

Formula

C₁₄H₂₈O₆

CAS No.

29836-26-8

Appearance

Solid

Color

White to off-white

SMILES

O[C@H]([C@H]([C@@H]([C@@H](CO)O1)O)O)[C@@H]1OCCCCCCCC

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

H₂O : 116.67 mg/mL (399.05 mM; Need ultrasonic)

DMSO : 100 mg/mL (342.03 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.4203 mL	17.1016 mL	34.2032 mL
5 mM	0.6841 mL	3.4203 mL	6.8406 mL
10 mM	0.3420 mL	1.7102 mL	3.4203 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

Protocol 1

Add each solvent one by one: 10% DMSO 40% PEG300 5% Tween-80 45% Saline
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.
Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
Protocol 2

Add each solvent one by one: 10% DMSO 90% (20% SBE-β-CD in Saline)
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown).
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL 20% SBE-β-CD in Saline, and mix evenly.
Preparation of 20% SBE-β-CD in Saline (4°C, storage for one week): 2 g SBE-β-CD powder is dissolved in 10 mL Saline, completely dissolve until clear.
Protocol 3

Add each solvent one by one: 10% DMSO 90% Corn Oil
Solubility: ≥ 2.5 mg/mL (8.55 mM); Clear solution

This protocol yields a clear solution of ≥ 2.5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (25.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.

The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).

Purity & Documentation

Purity: ≥98.0%

Select Batch:

Data Sheet (272 KB) SDS (393 KB)

COA (244 KB) HNMR (133 KB) OR (518 KB)

Handling Instructions (2659 KB)

References

[1]. Konidala P, et al. Molecular dynamics characterization of n-octyl-beta-D-glucopyranoside micelle structure in aqueous solution. J Mol Graph Model. 2006 Sep;25(1):77-86. [Content Brief]

[2]. Gould RJ, et al. Effects of octyl beta-glucoside on insulin binding to solubilized membrane receptors. Biochemistry. 1981 Nov 24;20(24):6776-81. [Content Brief]

[3]. Douglas L Miller, et al. The influence of octyl β-D-glucopyranoside on cell lysis induced by ultrasonic cavitation. J Acoust Soc Am. 2011 Nov;130(5):3482-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO / H₂O	1 mM	3.4203 mL	17.1016 mL	34.2032 mL	85.5081 mL
	5 mM	0.6841 mL	3.4203 mL	6.8406 mL	17.1016 mL
	10 mM	0.3420 mL	1.7102 mL	3.4203 mL	8.5508 mL
	15 mM	0.2280 mL	1.1401 mL	2.2802 mL	5.7005 mL
	20 mM	0.1710 mL	0.8551 mL	1.7102 mL	4.2754 mL
	25 mM	0.1368 mL	0.6841 mL	1.3681 mL	3.4203 mL
	30 mM	0.1140 mL	0.5701 mL	1.1401 mL	2.8503 mL
	40 mM	0.0855 mL	0.4275 mL	0.8551 mL	2.1377 mL
	50 mM	0.0684 mL	0.3420 mL	0.6841 mL	1.7102 mL
	60 mM	0.0570 mL	0.2850 mL	0.5701 mL	1.4251 mL
	80 mM	0.0428 mL	0.2138 mL	0.4275 mL	1.0689 mL
	100 mM	0.0342 mL	0.1710 mL	0.3420 mL	0.8551 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.