N-Propargylglycine

Cat. No.: HY-142035 Purity: 99.70%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

N-Propargylglycine is an orally active irreversible inhibitor of proline dehydrogenase (PRODH). N-Propargylglycine has antitumor activity and can be used in the study of neurodegenerative diseases.

For research use only. We do not sell to patients.

N-Propargylglycine Chemical Structure

CAS No. : 58160-95-5

Size	Stock	Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	In-stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	In-stock	Estimated Time of Arrival: December 31
Solid
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	Get quote
200 mg	Get quote

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Biological Activity
Purity & Documentation
References
Customer Review

Description

Molecular Weight

113.11

Formula

C₅H₇NO₂

CAS No.

58160-95-5

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(O)CNCC#C

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Store at room temperature, keep dry and cool

In solvent	-80°C	2 years
	-20°C	1 year

Solvent & Solubility

In Vitro:

DMSO : 8.33 mg/mL (73.65 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	8.8410 mL	44.2048 mL	88.4095 mL
5 mM	1.7682 mL	8.8410 mL	17.6819 mL
10 mM	0.8841 mL	4.4205 mL	8.8410 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.70%

Select Batch:

Data Sheet (265 KB) SDS (392 KB)

COA (243 KB) HNMR (271 KB) RP-HPLC (243 KB) MS (81 KB)

Handling Instructions (2659 KB)

References

[1]. Scott GK, et al. N-Propargylglycine: a unique suicide inhibitor of proline dehydrogenase with anticancer activity and brain-enhancing mitohormesis properties. Amino Acids. 2021 Dec;53(12):1927-1939. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	8.8410 mL	44.2048 mL	88.4095 mL	221.0238 mL
	5 mM	1.7682 mL	8.8410 mL	17.6819 mL	44.2048 mL
	10 mM	0.8841 mL	4.4205 mL	8.8410 mL	22.1024 mL
	15 mM	0.5894 mL	2.9470 mL	5.8940 mL	14.7349 mL
	20 mM	0.4420 mL	2.2102 mL	4.4205 mL	11.0512 mL
	25 mM	0.3536 mL	1.7682 mL	3.5364 mL	8.8410 mL
	30 mM	0.2947 mL	1.4735 mL	2.9470 mL	7.3675 mL
	40 mM	0.2210 mL	1.1051 mL	2.2102 mL	5.5256 mL
	50 mM	0.1768 mL	0.8841 mL	1.7682 mL	4.4205 mL
	60 mM	0.1473 mL	0.7367 mL	1.4735 mL	3.6837 mL