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NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling.

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NAADP Chemical Structure

NAADP Chemical Structure

CAS No. : 5502-96-5

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1 mg USD 340 In-stock
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Based on 1 publication(s) in Google Scholar

NAADP Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

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Description

NAADP, a nucleotide, is a Ca2+-mobilizing second messenger. NAADP is essential for initiation of Ca2+ signaling[1][2].

In Vitro

NAADP (2.5-10 μM) induces Ca2+ release from acidic intracellular stores in cytotoxic T lymphocytes[2].
NAADP (10 μM, 30 min) stimulates cytolytic granule exocytosis in cytotoxic T lymphocyte[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NAADP Related Antibodies
In Vivo

NAADP (0.181 mg/kg, i.v.) promotes autophagosome formation and protects the hepatocytes from injury in mice induced by LPS/GalN[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: LPS/GalN induced liver injury mice model[3]
Dosage: 0.181 mg/kg
Administration: i.v.
Result: Promoted autophagosome formation in in hepatocytes.
Showed higher levels of LC3II, p62, ATG5, and ATG7 in hepatocytes.
Molecular Weight

744.39

Formula

C21H27N6O18P3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=P(O)(O)O[C@H]1[C@H](N2C3=NC=NC(N)=C3N=C2)O[C@@H]([C@H]1O)COP(OP(OC[C@H]4O[C@@H]([N+]5=CC=CC(C(O)=O)=C5)[C@@H]([C@@H]4O)O)([O-])=O)(O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : 50 mg/mL (67.17 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.3434 mL 6.7169 mL 13.4338 mL
5 mM 0.2687 mL 1.3434 mL 2.6868 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 95.8%

COA (250 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.3434 mL 6.7169 mL 13.4338 mL 33.5845 mL
5 mM 0.2687 mL 1.3434 mL 2.6868 mL 6.7169 mL
10 mM 0.1343 mL 0.6717 mL 1.3434 mL 3.3585 mL
15 mM 0.0896 mL 0.4478 mL 0.8956 mL 2.2390 mL
20 mM 0.0672 mL 0.3358 mL 0.6717 mL 1.6792 mL
25 mM 0.0537 mL 0.2687 mL 0.5374 mL 1.3434 mL
30 mM 0.0448 mL 0.2239 mL 0.4478 mL 1.1195 mL
40 mM 0.0336 mL 0.1679 mL 0.3358 mL 0.8396 mL
50 mM 0.0269 mL 0.1343 mL 0.2687 mL 0.6717 mL
60 mM 0.0224 mL 0.1119 mL 0.2239 mL 0.5597 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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NAADP Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NAADP5502-96-5OthersCa2+nucleotidT lymphocytesliver injuryLPSInhibitorinhibitorinhibit

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