2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor 5-HT Receptor
  4. Nemonapride

Nemonapride  (Synonyms: YM-09151-2; Emonapride)

Cat. No.: HY-103415 Purity: 99.90%
COA Handling Instructions

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Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals.

For research use only. We do not sell to patients.

Nemonapride Chemical Structure

Nemonapride Chemical Structure

CAS No. : 75272-39-8

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1 mg USD 103 In-stock
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Based on 1 publication(s) in Google Scholar

Nemonapride Related Antibodies

Top Publications Citing Use of Products

View All Dopamine Receptor Isoform Specific Products:

View All Isoforms
Dopamine Receptor D1 Receptor D2 Receptor D3 Receptor D4 Receptor D5 Receptor

View All 5-HT Receptor Isoform Specific Products:

View All Isoforms
5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor 5-HT Receptor

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Description

Nemonapride is a highly potent dopamine D2 receptor antagonist with a Ki of 0.06 nM. Nemonapride also activates 5-HT1A receptor with an IC50 of 34 nM. Nemonapride is an antipsychotic that readily passes through the blood brain barrier and exhibits potent neuroleptic effects in animals[1][2][3].

IC50 & Target

5-HT1A Receptor

34 nM (IC50)

D2 Receptor

0.06 nM (Ki)

Molecular Weight

387.90

Formula

C21H26ClN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[C@H]1[C@@H](C)N(CC2=CC=CC=C2)CC1)C3=CC(Cl)=C(NC)C=C3OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMF : 20 mg/mL (51.56 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5780 mL 12.8899 mL 25.7798 mL
5 mM 0.5156 mL 2.5780 mL 5.1560 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMF 1 mM 2.5780 mL 12.8899 mL 25.7798 mL 64.4496 mL
5 mM 0.5156 mL 2.5780 mL 5.1560 mL 12.8899 mL
10 mM 0.2578 mL 1.2890 mL 2.5780 mL 6.4450 mL
15 mM 0.1719 mL 0.8593 mL 1.7187 mL 4.2966 mL
20 mM 0.1289 mL 0.6445 mL 1.2890 mL 3.2225 mL
25 mM 0.1031 mL 0.5156 mL 1.0312 mL 2.5780 mL
30 mM 0.0859 mL 0.4297 mL 0.8593 mL 2.1483 mL
40 mM 0.0644 mL 0.3222 mL 0.6445 mL 1.6112 mL
50 mM 0.0516 mL 0.2578 mL 0.5156 mL 1.2890 mL
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Nemonapride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nemonapride75272-39-8YM-09151-2 EmonaprideDopamine Receptor5-HT ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorInhibitorinhibitorinhibit

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