2. Cell Cycle/DNA Damage Epigenetics Apoptosis Stem Cell/Wnt
  3. PARP Apoptosis Wnt β-catenin
  4. Nesuparib

Nesuparib  (Synonyms: JPI-547/OCN-201)

Cat. No.: HY-145584 Purity: 99.43%
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Nesuparib (JPI-547) is an orally active PARP 1/2 and Tankyrase 1/2 inhibitor involved in the Wnt/β-catenin pathway. Nesuparib can induce cell cycle arrest and apoptosis and has anti-tumor activity. Nesuparib can be used to study cancer, neurological diseases and cardiovascular diseases.

For research use only. We do not sell to patients.

Nesuparib Chemical Structure

Nesuparib Chemical Structure

CAS No. : 2055357-64-5

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Nesuparib Related Antibodies

Top Publications Citing Use of Products

View All PARP Isoform Specific Products:

View All Isoforms
PARP PARP1 PARP2 PARP3 PARP4 TNKS1/PARP5A TNKS2/PARP5B PARP7 PARP10 PARP14 PARP15 PARP12 PARP16

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Description

Nesuparib (JPI-547) is an orally active PARP 1/2 and Tankyrase 1/2 inhibitor involved in the Wnt/β-catenin pathway. Nesuparib can induce cell cycle arrest and apoptosis and has anti-tumor activity. Nesuparib can be used to study cancer, neurological diseases and cardiovascular diseases[1][1][3].

IC50 & Target[2]

PARP1

 

PARP2

 

Molecular Weight

400.48

Formula

C23H24N6O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

N#CC1=CN=C(N2CCN(CC2)CC3=CC(NC(C4=C5NCCC4)=O)=C5C=C3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 62.5 mg/mL (156.06 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.4970 mL 12.4850 mL 24.9700 mL
5 mM 0.4994 mL 2.4970 mL 4.9940 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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g

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(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.4970 mL 12.4850 mL 24.9700 mL 62.4251 mL
5 mM 0.4994 mL 2.4970 mL 4.9940 mL 12.4850 mL
10 mM 0.2497 mL 1.2485 mL 2.4970 mL 6.2425 mL
15 mM 0.1665 mL 0.8323 mL 1.6647 mL 4.1617 mL
20 mM 0.1249 mL 0.6243 mL 1.2485 mL 3.1213 mL
25 mM 0.0999 mL 0.4994 mL 0.9988 mL 2.4970 mL
30 mM 0.0832 mL 0.4162 mL 0.8323 mL 2.0808 mL
40 mM 0.0624 mL 0.3121 mL 0.6243 mL 1.5606 mL
50 mM 0.0499 mL 0.2497 mL 0.4994 mL 1.2485 mL
60 mM 0.0416 mL 0.2081 mL 0.4162 mL 1.0404 mL
80 mM 0.0312 mL 0.1561 mL 0.3121 mL 0.7803 mL
100 mM 0.0250 mL 0.1249 mL 0.2497 mL 0.6243 mL
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Nesuparib Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nesuparib2055357-64-5JPI-547/OCN-201PARPApoptosisWntβ-cateninpoly ADP ribose polymerase Beta cateninHuman endometrioid endometrial cancer cell lineshuman pancreatic ductal adenocarcinoma (PDAC) cell linesInhibitorinhibitorinhibit

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