2. NF-κB
  3. NF-κB
  4. NF-κB-IN-11

NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay.

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NF-κB-IN-11 Chemical Structure

NF-κB-IN-11 Chemical Structure

CAS No. : 2768833-35-6

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Based on 1 publication(s) in Google Scholar

NF-κB-IN-11 Related Antibodies

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Description

NF-κB-IN-11 (Compound 3i) is a NF-κB inhibitor. NF-κB-IN-11 inhibits TNF-α induced activation of NF-κB pathway, and inhibits nuclear translocation of NF-κB. NF-κB-IN-11 down-regulates the expression levels of phosphor-IKK, IκBα, and NF-κB p65. NF-κB-IN-11 has anti-inflammatory activity, and alleviates dextran sulfate sodium-induced colitis in mice. NF-κB-IN-11 (p.o.) shows a MTD more than 1852 mg/kg in mice acute toxicity assay[1].

Molecular Weight

326.34

Formula

C19H18O5
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=C(C2OC1CC2C#CC3=CC=C(C)C=C3)C(OC)=O)OC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : ≥ 100 mg/mL (306.43 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0643 mL 15.3214 mL 30.6429 mL
5 mM 0.6129 mL 3.0643 mL 6.1286 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0643 mL 15.3214 mL 30.6429 mL 76.6072 mL
5 mM 0.6129 mL 3.0643 mL 6.1286 mL 15.3214 mL
10 mM 0.3064 mL 1.5321 mL 3.0643 mL 7.6607 mL
15 mM 0.2043 mL 1.0214 mL 2.0429 mL 5.1071 mL
20 mM 0.1532 mL 0.7661 mL 1.5321 mL 3.8304 mL
25 mM 0.1226 mL 0.6129 mL 1.2257 mL 3.0643 mL
30 mM 0.1021 mL 0.5107 mL 1.0214 mL 2.5536 mL
40 mM 0.0766 mL 0.3830 mL 0.7661 mL 1.9152 mL
50 mM 0.0613 mL 0.3064 mL 0.6129 mL 1.5321 mL
60 mM 0.0511 mL 0.2554 mL 0.5107 mL 1.2768 mL
80 mM 0.0383 mL 0.1915 mL 0.3830 mL 0.9576 mL
100 mM 0.0306 mL 0.1532 mL 0.3064 mL 0.7661 mL
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NF-κB-IN-11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NF-κB-IN-112768833-35-6NF-κBNuclear factor-κBNuclear factor-kappaBcolitisDSSanti-inflammatoryNF-κB pathwayTNF-αacute toxicity assayInhibitorinhibitorinhibit

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