2. GPCR/G Protein Neuronal Signaling
  3. Adrenergic Receptor
  4. Nifenalol hydrochloride

Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure.

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Nifenalol hydrochloride Chemical Structure

Nifenalol hydrochloride Chemical Structure

CAS No. : 5704-60-9

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5 mg USD 30 In-stock
10 mg USD 52 In-stock
25 mg USD 110 In-stock
50 mg USD 176 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nifenalol hydrochloride:

Nifenalol hydrochloride Related Antibodies

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Description

Nifenalol hydrochloride is a β-adrenergic receptor antagonist. Nifenalol hydrochloride induces the Early Afterdepolarization (EAD) effect. EAD is a phenomenon in cardiac electrophysiology that usually occurs during an action potential in ventricular muscle cells and can lead to arrhythmia. The EAD effect of Nifenalol hydrochloride can be blocked by Tetrodotoxin. Nifenalol hydrochloride is used in the study of conditions such as irregular heartbeat or high blood pressure[1].

IC50 & Target[1]

β-adrenoceptor

 

Molecular Weight

260.72

Formula

C11H17ClN2O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC(CNC(C)C)C1=CC=C([N+]([O-])=O)C=C1.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 250 mg/mL (958.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 50 mg/mL (191.78 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8355 mL 19.1777 mL 38.3553 mL
5 mM 0.7671 mL 3.8355 mL 7.6711 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O / DMSO 1 mM 3.8355 mL 19.1777 mL 38.3553 mL 95.8883 mL
5 mM 0.7671 mL 3.8355 mL 7.6711 mL 19.1777 mL
10 mM 0.3836 mL 1.9178 mL 3.8355 mL 9.5888 mL
15 mM 0.2557 mL 1.2785 mL 2.5570 mL 6.3926 mL
20 mM 0.1918 mL 0.9589 mL 1.9178 mL 4.7944 mL
25 mM 0.1534 mL 0.7671 mL 1.5342 mL 3.8355 mL
30 mM 0.1279 mL 0.6393 mL 1.2785 mL 3.1963 mL
40 mM 0.0959 mL 0.4794 mL 0.9589 mL 2.3972 mL
50 mM 0.0767 mL 0.3836 mL 0.7671 mL 1.9178 mL
60 mM 0.0639 mL 0.3196 mL 0.6393 mL 1.5981 mL
80 mM 0.0479 mL 0.2397 mL 0.4794 mL 1.1986 mL
100 mM 0.0384 mL 0.1918 mL 0.3836 mL 0.9589 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nifenalol hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nifenalol5704-60-9Adrenergic ReceptorBeta ReceptorEarly AfterdepolarizationEADhigh blood pressureirregular heartbeatarrhythmiacardiac electrophysiologyInhibitorinhibitorinhibit

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