(Nle4)-α-MSH

Cat. No.: HY-P3645: FAQs
Data Sheet Handling Instructions

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(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment.

For research use only. We do not sell to patients.

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(Nle4)-α-MSH Chemical Structure

CAS No. : 64887-70-3

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Biological Activity
Purity & Documentation
References
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Description	(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment^[1].
IC₅₀ & Target	tyrosinase; melanoma adenylate cyclase^[1]
In Vitro	(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity^[1]. (Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)^[1]. (Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins^[1]. (Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase^[1]. MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only. (Nle4)-α-MSH Related Antibodies
Molecular Weight	1646.85
Formula	C₇₈H₁₁₁N₂₁O₁₉
CAS No.	64887-70-3
Sequence Shortening	Ac-SYS-{Nle}-EHFRWGKPV-NH2
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (260 KB) Handling Instructions (2659 KB)
References	[1]. Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8. [Content Brief]

(Nle4)-α-MSH Related Classifications

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(Nle4)-α-MSH64887-70-3Melanocortin ReceptorMC Receptorfrog skinheat-alkalimelanocyte-stimulating hormonetyrosinase activityadenylate cyclaseInhibitorinhibitorinhibit

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