(Nle4)-α-MSH 

(Nle4)-α-MSH is a synthetic analogue of α-MSH (HY-P0252), a melanocyte-stimulating hormone. (Nle4)-α-MSH reversibly darkens frog skins and also exhibits prolonged activity after heat-alkali treatment^[1].

tyrosinase; melanoma adenylate cyclase^[1]

(Nle4)-α-MSH shows a better bioactivity than α-MSH in frog skin bioassay, activation of mouse melanoma adenylate cyclase, and stimulation of mouse melanoma cell tyrosinase activity^[1].
(Nle4)-α-MSH (0.1 nM; 0.5, 4, 8 h) stimulates tyrosinase activity in melanoma cells (NCTC 3960)^[1].
(Nle4)-α-MSH (0.1 nM; 1-4 h) increases biological activity of melanotropins, indicating darkening response of frog skins^[1].
(Nle4)-α-MSH (0.1 μg) also activates mouse melanoma adenylate cyclase^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

1646.85

C₇₈H₁₁₁N₂₁O₁₉

64887-70-3

Ac-SYS-{Nle}-EHFRWGKPV-NH2

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Sawyer TK, et al. 4-Norleucine, 7-D-phenylalanine-alpha-melanocyte-stimulating hormone: a highly potent alpha-melanotropin with ultralong biological activity. Proc Natl Acad Sci U S A. 1980 Oct;77(10):5754-8.  [Content Brief]