2. Immunology/Inflammation
  3. NOD-like Receptor (NLR)
  4. NVP-DFV890

NVP-DFV890  (Synonyms: NLRP3 antagonist 2)

Cat. No.: HY-155876 Purity: 98.47%
SDS COA Handling Instructions

Molarity Calculator

NVP-DFV890 (comopound 102) is a NLRP3 antagonist. NVP-DFV890 can be used for osteoarthritis research.

For research use only. We do not sell to patients.

NVP-DFV890 Chemical Structure

NVP-DFV890 Chemical Structure

CAS No. : 2271394-34-2

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 384 In-stock
Solution
10 mM * 1 mL in DMSO USD 384 In-stock
Solid
5 mg USD 415 In-stock
10 mg USD 670 In-stock
25 mg USD 1340 In-stock
50 mg USD 2140 In-stock
100 mg   Get quote  
200 mg   Get quote  

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This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

NVP-DFV890 Related Antibodies

Top Publications Citing Use of Products

View All NOD-like Receptor (NLR) Isoform Specific Products:

View All Isoforms
NLRP3 NLRP1 NOD1 NOD2

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NVP-DFV890 (comopound 102) is a NLRP3 antagonist. NVP-DFV890 can be used for osteoarthritis research[1].

IC50 & Target

NLRP3

 

Molecular Weight

420.55

Formula

C19H24N4O3S2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(N[S@](=N)(C(S1)=CN=C1C(C)(O)C)=O)NC2=C(CCC3)C3=CC4=C2CCC4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (237.78 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3778 mL 11.8892 mL 23.7784 mL
5 mM 0.4756 mL 2.3778 mL 4.7557 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

Select the appropriate dissolution method based on your experimental animal and administration route.

For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for in vivo experiments, it is recommended to prepare freshly and use it on the same day.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% Saline

    Solubility: ≥ 5 mg/mL (11.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown).

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 400 μL PEG300, and mix evenly; then add 50 μL Tween-80 and mix evenly; then add 450 μL Saline to adjust the volume to 1 mL.

    Preparation of Saline: Dissolve 0.9 g sodium chloride in ddH₂O and dilute to 100 mL to obtain a clear Saline solution.
  • Protocol 2

    Add each solvent one by one:  10% DMSO    90% Corn Oil

    Solubility: ≥ 5 mg/mL (11.89 mM); Clear solution

    This protocol yields a clear solution of ≥ 5 mg/mL (saturation unknown). If the continuous dosing period exceeds half a month, please choose this protocol carefully.

    Taking 1 mL working solution as an example, add 100 μL DMSO stock solution (50.0 mg/mL) to 900 μL Corn oil, and mix evenly.

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
%
DMSO +
% 
+
%
Tween-80 +
%
Saline
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Calculation results:
Working solution concentration: mg/mL
Method for preparing stock solution: mg drug dissolved in μL  DMSO (Stock solution concentration: mg/mL).
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only. If necessary, please contact MedChemExpress (MCE).
Method for preparing in vivo working solution for animal experiments: Take μL DMSO stock solution, add μL . μL , mix evenly, next add μL Tween 80, mix evenly, then add μL Saline.
 If the continuous dosing period exceeds half a month, please choose this protocol carefully.
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation

Purity: 98.47%

SDS (251 KB)

COA (252 KB) HNMR (258 KB) RP-HPLC (251 KB) LCMS (93 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3778 mL 11.8892 mL 23.7784 mL 59.4460 mL
5 mM 0.4756 mL 2.3778 mL 4.7557 mL 11.8892 mL
10 mM 0.2378 mL 1.1889 mL 2.3778 mL 5.9446 mL
15 mM 0.1585 mL 0.7926 mL 1.5852 mL 3.9631 mL
20 mM 0.1189 mL 0.5945 mL 1.1889 mL 2.9723 mL
25 mM 0.0951 mL 0.4756 mL 0.9511 mL 2.3778 mL
30 mM 0.0793 mL 0.3963 mL 0.7926 mL 1.9815 mL
40 mM 0.0594 mL 0.2972 mL 0.5945 mL 1.4861 mL
50 mM 0.0476 mL 0.2378 mL 0.4756 mL 1.1889 mL
60 mM 0.0396 mL 0.1982 mL 0.3963 mL 0.9908 mL
80 mM 0.0297 mL 0.1486 mL 0.2972 mL 0.7431 mL
100 mM 0.0238 mL 0.1189 mL 0.2378 mL 0.5945 mL
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NVP-DFV890 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NVP-DFV8902271394-34-2NLRP3 antagonist 2NOD-like Receptor (NLR)osteoarthritisInhibitorinhibitorinhibit

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