2. Membrane Transporter/Ion Channel Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. iGluR TRP Channel ERK
  4. Brophenexin free base

Brophenexin free base  (Synonyms: NMDAR/TRPM4-IN-2 free base)

Cat. No.: HY-139192A Purity: 99.24%
SDS COA Handling Instructions Technical Support

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.

For research use only. We do not sell to patients.

Brophenexin free base Chemical Structure

Brophenexin free base Chemical Structure

CAS No. : 1353979-43-7

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Liquid
5 mg In-stock
10 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Brophenexin free base:

Brophenexin free base Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Brophenexin free base

View All iGluR Isoform Specific Products:

View All Isoforms
AMPA Receptor NMDA Receptor Kainate Receptor

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Brophenexin free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. Brophenexin free base shows neuroprotective activity. Brophenexin free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. Brophenexin free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

IC50 & Target

NMDA Receptor

 

In Vitro

Brophenexin free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1].
Brophenexin free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Brophenexin free base Related Antibodies
Molecular Weight

257.18

Formula

C11H17BrN2
CAS No.
Appearance

Liquid (Density: 1.293 g/cm3)

Color

Colorless to light yellow

SMILES

NCCN(CC1=CC=CC(Br)=C1)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (388.83 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8883 mL 19.4416 mL 38.8833 mL
5 mM 0.7777 mL 3.8883 mL 7.7767 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

SDS (417 KB)

COA (243 KB) HNMR (414 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8883 mL 19.4416 mL 38.8833 mL 97.2082 mL
5 mM 0.7777 mL 3.8883 mL 7.7767 mL 19.4416 mL
10 mM 0.3888 mL 1.9442 mL 3.8883 mL 9.7208 mL
15 mM 0.2592 mL 1.2961 mL 2.5922 mL 6.4805 mL
20 mM 0.1944 mL 0.9721 mL 1.9442 mL 4.8604 mL
25 mM 0.1555 mL 0.7777 mL 1.5553 mL 3.8883 mL
30 mM 0.1296 mL 0.6481 mL 1.2961 mL 3.2403 mL
40 mM 0.0972 mL 0.4860 mL 0.9721 mL 2.4302 mL
50 mM 0.0778 mL 0.3888 mL 0.7777 mL 1.9442 mL
60 mM 0.0648 mL 0.3240 mL 0.6481 mL 1.6201 mL
80 mM 0.0486 mL 0.2430 mL 0.4860 mL 1.2151 mL
100 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9721 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Brophenexin free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Brophenexin1353979-43-7NMDAR/TRPM4-IN-2iGluRTRP ChannelERKIonotropic glutamate receptorsTransient receptor potential channelsExtracellular signal regulated kinasesN-methyl-D-aspartate receptorsneurodegenerative diseaseshippocampal neuronsneuroprotective activitybrain damagetransient receptor potential cation channel subfamily M member 4Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Salutation

Applicant Name *

 

Email Address *

Phone Number *

 

Organization Name *

Department *

 

Requested quantity *

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Brophenexin free base
Cat. No.:
HY-139192A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

English - EN (417 KB) Français - FR (417 KB) Deutsch - DE (417 KB) Norwegian - NO (417 KB) Español - ES (417 KB) Swedish - SV (417 KB)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.