2. Membrane Transporter/Ion Channel Neuronal Signaling Stem Cell/Wnt MAPK/ERK Pathway
  3. iGluR TRP Channel ERK
  4. NMDAR/TRPM4-IN-2 free base

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss.

For research use only. We do not sell to patients.

NMDAR/TRPM4-IN-2 free base Chemical Structure

NMDAR/TRPM4-IN-2 free base Chemical Structure

CAS No. : 1353979-43-7

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 USD 55 In-stock
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Liquid
5 mg USD 50 In-stock
10 mg USD 75 In-stock
50 mg USD 230 In-stock
100 mg USD 368 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of NMDAR/TRPM4-IN-2 free base:

NMDAR/TRPM4-IN-2 free base Related Antibodies

Top Publications Citing Use of Products

View All iGluR Isoform Specific Products:

View All Isoforms
AMPA Receptor NMDA Receptor Kainate Receptor

View All TRP Channel Isoform Specific Products:

View All Isoforms
TRPC TRPM TRPV TRPA TRPML

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

NMDAR/TRPM4-IN-2 free base (compound 8) is a potent NMDAR/TRPM4 interaction interface inhibitor. NMDAR/TRPM4-IN-2 free base shows neuroprotective activity. NMDAR/TRPM4-IN-2 free base prevents NMDA-induced cell death and mitochondrial dysfunction in hippocampal neurons, with an IC50 of 2.1 μM. NMDAR/TRPM4-IN-2 free base protects mice from MCAO-induced brain damage and NMDA-induced retinal ganglion cell loss[1].

IC50 & Target

NMDA Receptor

 

In Vitro

NMDAR/TRPM4-IN-2 free base (compound 8) (0-10 μM) reduces the interactions of GluN2A and GluN2B with TRPM4 in a dose-dependent manner[1].
NMDAR/TRPM4-IN-2 free base eliminates the CREB shutoff pathway and restores ERK1/2 activation and IEG induction while sparing the synaptic activity-driven, transcription-promoting activities of NMDARs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NMDAR/TRPM4-IN-2 free base Related Antibodies
Molecular Weight

257.17

Formula

C11H17BrN2
CAS No.
Appearance

Liquid (Density: 1.293 g/cm3)

Color

Colorless to light yellow

SMILES

NCCN(CC1=CC=CC(Br)=C1)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (388.85 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.8885 mL 19.4424 mL 38.8848 mL
5 mM 0.7777 mL 3.8885 mL 7.7770 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: 99.24%

SDS (417 KB)

COA (243 KB) HNMR (414 KB) LCMS (90 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.8885 mL 19.4424 mL 38.8848 mL 97.2120 mL
5 mM 0.7777 mL 3.8885 mL 7.7770 mL 19.4424 mL
10 mM 0.3888 mL 1.9442 mL 3.8885 mL 9.7212 mL
15 mM 0.2592 mL 1.2962 mL 2.5923 mL 6.4808 mL
20 mM 0.1944 mL 0.9721 mL 1.9442 mL 4.8606 mL
25 mM 0.1555 mL 0.7777 mL 1.5554 mL 3.8885 mL
30 mM 0.1296 mL 0.6481 mL 1.2962 mL 3.2404 mL
40 mM 0.0972 mL 0.4861 mL 0.9721 mL 2.4303 mL
50 mM 0.0778 mL 0.3888 mL 0.7777 mL 1.9442 mL
60 mM 0.0648 mL 0.3240 mL 0.6481 mL 1.6202 mL
80 mM 0.0486 mL 0.2430 mL 0.4861 mL 1.2151 mL
100 mM 0.0389 mL 0.1944 mL 0.3888 mL 0.9721 mL
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NMDAR/TRPM4-IN-2 free base Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NMDAR/TRPM4-IN-21353979-43-7iGluRTRP ChannelERKIonotropic glutamate receptorsTransient receptor potential channelsExtracellular signal regulated kinasesN-methyl-D-aspartate receptorsneurodegenerative diseaseshippocampal neuronsneuroprotective activitybrain damagetransient receptor potential cation channel subfamily M member 4Inhibitorinhibitorinhibit

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