Norethindrone-d₆

Name: Norethindrone-d 6
Brand: MedChemExpress
SKU: HY-B0554S
Rating: 4.5 (1 reviews)

Cat. No.: HY-B0554S: FAQs
Data Sheet SDS COA Handling Instructions

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Norethindrone-d₆ is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Norethindrone-d<sub>6</sub> Chemical Structure

Norethindrone-d₆ Chemical Structure

CAS No. : 2376036-05-2

Size	Price	Stock	Quantity
5 mg	USD 460	In-stock	Estimated Time of Arrival: December 31
1 mg		Get quote	Estimated Time of Arrival: December 31

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Based on 1 publication(s) in Google Scholar

Other Forms of Norethindrone-d₆:

Norethindrone In-stock

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Biological Activity
Purity & Documentation
References
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Description

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

304.46

Formula

C₂₀H₂₀D₆O₂

CAS No.

2376036-05-2

Unlabeled CAS

68-22-4

Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)([H])CC1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 25 mg/mL (82.11 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.2845 mL	16.4225 mL	32.8450 mL
5 mM	0.6569 mL	3.2845 mL	6.5690 mL
10 mM	0.3285 mL	1.6423 mL	3.2845 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.60%

Select Batch:

Data Sheet (278 KB) SDS (419 KB)

COA (257 KB) HNMR (295 KB) RP-HPLC (834 KB)

Handling Instructions (2659 KB)

References

[1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. [Content Brief]

[2]. Muneyyirci-Delale O, et al. Effect of norethindrone acetate in the treatment of symptomatic endometriosis. Int J Fertil Womens Med. 1998 Jan-Feb;43(1):24-7. [Content Brief]

[3]. Kaser DJ, et al. Use of norethindrone acetate alone for postoperative suppression of endometriosis symptoms. J Pediatr Adolesc Gynecol. 2012 Apr;25(2):105-8. [Content Brief]

[4]. Maier WE, et al. Pharmacology and toxicology of ethinyl estradiol and norethindrone acetate in experimental animals. Regul Toxicol Pharmacol. 2001 Aug;34(1):53-61. [Content Brief]

[5]. Cheng DC, et al. Norethindrone acetate inhibition of triglyceride synthesis and release by rat hepatocytes. Atherosclerosis. 1983 Jan;46(1):41-8. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.2845 mL	16.4225 mL	32.8450 mL	82.1126 mL
	5 mM	0.6569 mL	3.2845 mL	6.5690 mL	16.4225 mL
	10 mM	0.3285 mL	1.6423 mL	3.2845 mL	8.2113 mL
	15 mM	0.2190 mL	1.0948 mL	2.1897 mL	5.4742 mL
	20 mM	0.1642 mL	0.8211 mL	1.6423 mL	4.1056 mL
	25 mM	0.1314 mL	0.6569 mL	1.3138 mL	3.2845 mL
	30 mM	0.1095 mL	0.5474 mL	1.0948 mL	2.7371 mL
	40 mM	0.0821 mL	0.4106 mL	0.8211 mL	2.0528 mL
	50 mM	0.0657 mL	0.3285 mL	0.6569 mL	1.6423 mL
	60 mM	0.0547 mL	0.2737 mL	0.5474 mL	1.3685 mL
	80 mM	0.0411 mL	0.2053 mL	0.4106 mL	1.0264 mL