2. Others Vitamin D Related/Nuclear Receptor
  3. Isotope-Labeled Compounds Progesterone Receptor
  4. Norethindrone-d6

Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

For research use only. We do not sell to patients.

Norethindrone-d<sub>6</sub> Chemical Structure

Norethindrone-d6 Chemical Structure

CAS No. : 2376036-05-2

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1 mg USD 184 In-stock
5 mg USD 460 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Norethindrone-d6:

Norethindrone-d6 Related Antibodies

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Description

Norethindrone-d6 is the deuterium labeled Norethindrone. Norethindrone is a female progestin approved by FDA for the treatment of endometriosis, uterine bleeding caused by abnormal hormone levels, and secondary amenorrhea. Norethindrone-d6 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

In Vitro

Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Norethindrone-d6 Related Antibodies
Molecular Weight

304.46

Formula

C20H20D6O2
CAS No.
Unlabeled CAS

68-22-4
Appearance

Solid

Color

White to off-white

SMILES

C[C@@]12[C@](CC[C@@]2(O)C#C)([H])[C@@]3([H])[C@]([C@]4([2H])C(C([2H])([2H])C3)=C([2H])C(C([2H])([2H])C4)=O)([H])CC1
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (82.11 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.2845 mL 16.4225 mL 32.8450 mL
5 mM 0.6569 mL 3.2845 mL 6.5690 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.2845 mL 16.4225 mL 32.8450 mL 82.1126 mL
5 mM 0.6569 mL 3.2845 mL 6.5690 mL 16.4225 mL
10 mM 0.3285 mL 1.6423 mL 3.2845 mL 8.2113 mL
15 mM 0.2190 mL 1.0948 mL 2.1897 mL 5.4742 mL
20 mM 0.1642 mL 0.8211 mL 1.6423 mL 4.1056 mL
25 mM 0.1314 mL 0.6569 mL 1.3138 mL 3.2845 mL
30 mM 0.1095 mL 0.5474 mL 1.0948 mL 2.7371 mL
40 mM 0.0821 mL 0.4106 mL 0.8211 mL 2.0528 mL
50 mM 0.0657 mL 0.3285 mL 0.6569 mL 1.6423 mL
60 mM 0.0547 mL 0.2737 mL 0.5474 mL 1.3685 mL
80 mM 0.0411 mL 0.2053 mL 0.4106 mL 1.0264 mL
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Norethindrone-d6 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Norethindrone-d62376036-05-2Isotope-Labeled CompoundsProgesterone ReceptorNR3C3Inhibitorinhibitorinhibit

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