2. Metabolic Enzyme/Protease Anti-infection
  3. Aminoacyl-tRNA Synthetase Fungal
  4. NP-BTA

NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM.

For research use only. We do not sell to patients.

NP-BTA Chemical Structure

NP-BTA Chemical Structure

CAS No. : 544420-99-7

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Based on 1 publication(s) in Google Scholar

NP-BTA Related Antibodies

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Description

NP-BTA is an allosteric inhibitor for glutaminyl-tRNA synthetase (GlnRS). NP-BTA exhibits antifungal efficacy against Candida albicans, with MIC50 of 6.25 μM[1].

In Vitro

NP-BTA (300 μM) inhibits GlnRS through binding His6-Gln4, with KD of 180 nM, and thus inhibits aminoacylation of tRNAGln with IC50 of 106 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

NP-BTA Related Antibodies
In Vivo

NP-BTA (0.096–0.27 g 2% NP-BTA cream, application, twice daily for 7 days) protects immunosuppressed CD-1 mice from infection of T. mentagrophytes conidia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: T. mentagrophytes infected immunosuppressed CD-1 mice[1]
Dosage: 0.096–0.27 g 2% NP-BTA cream
Administration: Topical application, twice daily for 7 days
Result: Reduced fungal burden.
Molecular Weight

231.27

Formula

C11H9N3OS
CAS No.
SMILES

O=C(NC1=NC=CC=N1)/C=C/C2=CC=CS2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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NP-BTA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

NP-BTA544420-99-7Aminoacyl-tRNA SynthetaseFungaltRNA Synthetase, aaRSCandida albicansallostericCD-1 miceT. mentagrophytesInhibitorinhibitorinhibit

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