2. NF-κB
  3. Keap1-Nrf2
  4. Nrf2 activator-1

Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1).

For research use only. We do not sell to patients.

Nrf2 activator-1 Chemical Structure

Nrf2 activator-1 Chemical Structure

CAS No. : 2230697-41-1

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Based on 1 publication(s) in Google Scholar

Nrf2 activator-1 Related Antibodies

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Description

Nrf2 activator-1 is a potent activator of NF-E2 related factor 2 (Nrf2). Nrf2 activator-1 has the potential for the research of COPD and other respiratory diseases, including asthma, Acute Lung Injury (ALI), Acute Respiratory Distress Syndrome (ARDS) and pulmonary fibrosis (extracted from patent WO2018109647A1)[1].

IC50 & Target

Nrf2[1]
Molecular Weight

578.68

Formula

C30H34N4O6S
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

CCOC(C[C@@H](C1=CC(CN2S(=O)(C3=CC=CC=C3O[C@@H](C2)C)=O)=C(C=C1)C)C4=CC(OC)=C(N(N=N5)C)C5=C4)=O
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Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (172.81 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7281 mL 8.6404 mL 17.2807 mL
5 mM 0.3456 mL 1.7281 mL 3.4561 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7281 mL 8.6404 mL 17.2807 mL 43.2018 mL
5 mM 0.3456 mL 1.7281 mL 3.4561 mL 8.6404 mL
10 mM 0.1728 mL 0.8640 mL 1.7281 mL 4.3202 mL
15 mM 0.1152 mL 0.5760 mL 1.1520 mL 2.8801 mL
20 mM 0.0864 mL 0.4320 mL 0.8640 mL 2.1601 mL
25 mM 0.0691 mL 0.3456 mL 0.6912 mL 1.7281 mL
30 mM 0.0576 mL 0.2880 mL 0.5760 mL 1.4401 mL
40 mM 0.0432 mL 0.2160 mL 0.4320 mL 1.0800 mL
50 mM 0.0346 mL 0.1728 mL 0.3456 mL 0.8640 mL
60 mM 0.0288 mL 0.1440 mL 0.2880 mL 0.7200 mL
80 mM 0.0216 mL 0.1080 mL 0.2160 mL 0.5400 mL
100 mM 0.0173 mL 0.0864 mL 0.1728 mL 0.4320 mL
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Nrf2 activator-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nrf2 activator-12230697-41-1Keap1-Nrf2Nrf2activatorCOPDasthmaALIARDSpulmonary fibrosisInhibitorinhibitorinhibit

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