2. Immunology/Inflammation
  3. NO Synthase
  4. Nω-Propyl-L-arginine hydrochloride

Nω-Propyl-L-arginine hydrochloride  (Synonyms: N-omega-Propyl-L-arginine hydrochloride)

Cat. No.: HY-102062A Purity: 98.28%
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Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS).

For research use only. We do not sell to patients.

Nω-Propyl-L-arginine hydrochloride Chemical Structure

Nω-Propyl-L-arginine hydrochloride Chemical Structure

CAS No. : 2321366-46-3

Size Price Stock Quantity
5 mg USD 52 In-stock
10 mg USD 98 In-stock
25 mg USD 230 In-stock
50 mg USD 410 In-stock
100 mg USD 730 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Nω-Propyl-L-arginine hydrochloride:

Nω-Propyl-L-arginine hydrochloride Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Nω-Propyl-L-arginine hydrochloride

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nNOS iNOS eNOS

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride is a potent, competitive, and highly selective inhibitor of neuronal nitric oxide synthase (nNOS), with a Ki of 57 nM. Nω-Propyl-L-arginine hydrochloride displays a 149-fold selectivity for nNOS over endothelial NOS (eNOS)[1][2].

In Vivo

Nω-Propyl-L-arginine (N-omega-Propyl-L-arginine) hydrochloride (20 mg/kg; i.p.) blocks both phencyclidine-induced disruption of prepulse inhibition and phencyclidine-induced stimulation of locomotor activity[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male NMRI mice (30-40 g) (phencyclidine-induced stimulation)[2]
Dosage: 20 mg/kg
Administration: I.p.
Result: Markedly reduced the phencyclidineinduced disruption of prepulse inhibition and significantly reduced the phencyclidine-induced stimulation of locomotor activity.
Molecular Weight

252.74

Formula

C9H21ClN4O2
CAS No.
Appearance

Oil

Color

Colorless to off-white

SMILES

N[C@@H](CCCNC(NCCC)=N)C(O)=O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 25 mg/mL (98.92 mM; Need ultrasonic and warming; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

H2O : 25 mg/mL (98.92 mM; Need ultrasonic and warming)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.9566 mL 19.7832 mL 39.5664 mL
5 mM 0.7913 mL 3.9566 mL 7.9133 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO / H2O 1 mM 3.9566 mL 19.7832 mL 39.5664 mL 98.9159 mL
5 mM 0.7913 mL 3.9566 mL 7.9133 mL 19.7832 mL
10 mM 0.3957 mL 1.9783 mL 3.9566 mL 9.8916 mL
15 mM 0.2638 mL 1.3189 mL 2.6378 mL 6.5944 mL
20 mM 0.1978 mL 0.9892 mL 1.9783 mL 4.9458 mL
25 mM 0.1583 mL 0.7913 mL 1.5827 mL 3.9566 mL
30 mM 0.1319 mL 0.6594 mL 1.3189 mL 3.2972 mL
40 mM 0.0989 mL 0.4946 mL 0.9892 mL 2.4729 mL
50 mM 0.0791 mL 0.3957 mL 0.7913 mL 1.9783 mL
60 mM 0.0659 mL 0.3297 mL 0.6594 mL 1.6486 mL
80 mM 0.0495 mL 0.2473 mL 0.4946 mL 1.2364 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Nω-Propyl-L-arginine hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nω-Propyl-L-arginine2321366-46-3N-omega-Propyl-L-arginineNO SynthaseNitric oxide synthasesNOSlocomotoractivityeNOSstimulatoryantipsychoticpsychotomimeticInhibitorinhibitorinhibit

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