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O-allylvanillin is O-allylchalcone derivative with anti-cancer effects. O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively.

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O-allylvanillin Chemical Structure

O-allylvanillin Chemical Structure

CAS No. : 22280-95-1

Size Price Stock Quantity
Liquid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Liquid
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

O-allylvanillin Related Antibodies

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Description

O-allylvanillin is O-allylchalcone derivative with anti-cancer effects[1]. O-allylvanillin inhibits THP-1, HL60, Hep-G2, MCF-7 cells growth with IC50 values of 74.76 μM, 63.52 μM, 90.99 μM, and 90.11 μM, respectively[1].

Cellular Effect
Cell Line Type Value Description References
ADR5000 cell line IC50
3.48 μM
Compound: 1a
Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human CEM/ADR5000 cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
CCRF-CEM IC50
14.04 μM
Compound: 1a
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human CCRF-CEM cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
HCT-116 IC50
5.77 μM
Compound: 1a
Cytotoxicity against human HCT-116 p53+/+ cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human HCT-116 p53+/+ cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
HCT-116 IC50
8.02 μM
Compound: 1a
Cytotoxicity against human HCT-116 p53-/- cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human HCT-116 p53-/- cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
HepG2 IC50
10.46 μM
Compound: 1a
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human HepG2 cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
MDA-MB-231 IC50
14.99 μM
Compound: 1a
Cytotoxicity against human MDA-MB-231 pcDNA cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human MDA-MB-231 pcDNA cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
U-87MG ATCC IC50
7.5 μM
Compound: 1a
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by RRA assay
Cytotoxicity against human U87 cells assessed as reduction in cell viability after 72 hrs by RRA assay
[PMID: 33508467]
Molecular Weight

192.21

Formula

C11H12O3
CAS No.
Appearance

Liquid (Density: 1.084±0.06 g/cm3)

Color

Colorless to light yellow

SMILES

O=CC1=CC=C(OCC=C)C(OC)=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (520.25 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 5.2025 mL 26.0127 mL 52.0253 mL
5 mM 1.0405 mL 5.2025 mL 10.4051 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 5.2025 mL 26.0127 mL 52.0253 mL 130.0634 mL
5 mM 1.0405 mL 5.2025 mL 10.4051 mL 26.0127 mL
10 mM 0.5203 mL 2.6013 mL 5.2025 mL 13.0063 mL
15 mM 0.3468 mL 1.7342 mL 3.4684 mL 8.6709 mL
20 mM 0.2601 mL 1.3006 mL 2.6013 mL 6.5032 mL
25 mM 0.2081 mL 1.0405 mL 2.0810 mL 5.2025 mL
30 mM 0.1734 mL 0.8671 mL 1.7342 mL 4.3354 mL
40 mM 0.1301 mL 0.6503 mL 1.3006 mL 3.2516 mL
50 mM 0.1041 mL 0.5203 mL 1.0405 mL 2.6013 mL
60 mM 0.0867 mL 0.4335 mL 0.8671 mL 2.1677 mL
80 mM 0.0650 mL 0.3252 mL 0.6503 mL 1.6258 mL
100 mM 0.0520 mL 0.2601 mL 0.5203 mL 1.3006 mL
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O-allylvanillin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

O-allylvanillin22280-95-1OthersTHP-1HL60Hep-G2DU-145MCF-7anti-cancerInhibitorinhibitorinhibit

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