2. Metabolic Enzyme/Protease
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  4. OF-Deg-Lin

OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

For research use only. We do not sell to patients.

OF-Deg-Lin Chemical Structure

OF-Deg-Lin Chemical Structure

CAS No. : 1853202-95-5

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Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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Solution
10 mM * 1 mL in DMSO In-stock
Oil
5 mg In-stock
10 mg In-stock
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Based on 1 publication(s) in Google Scholar

OF-Deg-Lin Related Antibodies

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  • Biological Activity

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Description

OF-Deg-Lin is an ionizable amino lipid used for the generation of Lipid nanoparticles (LNPs).

In Vitro

OF-Deg-Lin is an ionizable lipid material that forms lipid nanoparticles (LNPs) with components such as cholesterol, lipid-anchored polyethylene glycol (PEG), phospholipids and mRNA for in vivo delivery of mRNA. OF-Deg-Lin LNPs specifically delivers mRNA to the spleen, inducing protein expression in the spleen, while less protein expression in other organs such as the liver[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OF-Deg-Lin Related Antibodies
In Vivo

OF-Deg-Lin (iv, single dose) induces the majority of protein expression in the spleen, labels a certain proportion of B cells in the spleen, while causing minimal translation in other organs in mouse models[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 mouse models[2]
Dosage: 0.75-2.25 mg/kg in form of OF-Deg-Lin mRNA LNPs
Administration: iv, single dose
Result: Induced 85% of total protein production in the spleen, labeled ca. 7% of the total B cell population in C57BL/6 mice.
Molecular Weight

1482.28

Formula

C92H160N4O10
CAS No.
Appearance

Oil

Color

Colorless to light yellow

SMILES

CCCCC/C=C\C/C=C\CCCCCCCC(OCCN(CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCCCC1C(NC(C(N1)=O)CCCCN(CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)CCOC(CCCCCCC/C=C\C/C=C\CCCCC)=O)=O)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (67.46 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.6746 mL 3.3732 mL 6.7464 mL
5 mM 0.1349 mL 0.6746 mL 1.3493 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.6746 mL 3.3732 mL 6.7464 mL 16.8659 mL
5 mM 0.1349 mL 0.6746 mL 1.3493 mL 3.3732 mL
10 mM 0.0675 mL 0.3373 mL 0.6746 mL 1.6866 mL
15 mM 0.0450 mL 0.2249 mL 0.4498 mL 1.1244 mL
20 mM 0.0337 mL 0.1687 mL 0.3373 mL 0.8433 mL
25 mM 0.0270 mL 0.1349 mL 0.2699 mL 0.6746 mL
30 mM 0.0225 mL 0.1124 mL 0.2249 mL 0.5622 mL
40 mM 0.0169 mL 0.0843 mL 0.1687 mL 0.4216 mL
50 mM 0.0135 mL 0.0675 mL 0.1349 mL 0.3373 mL
60 mM 0.0112 mL 0.0562 mL 0.1124 mL 0.2811 mL
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OF-Deg-Lin Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OF-Deg-Lin1853202-95-5LiposomeC57BL/6 mouseInhibitorinhibitorinhibit

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