2. GPCR/G Protein Neuronal Signaling Autophagy Apoptosis
  3. 5-HT Receptor Dopamine Receptor mAChR Adrenergic Receptor Autophagy Mitophagy Apoptosis
  4. Olanzapine-d3

Olanzapine-d3  (Synonyms: LY170053-d3)

Cat. No.: HY-14541S Purity: 99.09%
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Olanzapine-d3 is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

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Olanzapine-d<sub>3</sub> Chemical Structure

Olanzapine-d3 Chemical Structure

CAS No. : 786686-79-1

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Based on 1 publication(s) in Google Scholar

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Olanzapine-d3 Related Antibodies

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Description

Olanzapine-d3 is the deuterium labeled Olanzapine. Olanzapine is a selective, orally active monoaminergic antagonist with high affinity binding to serotonin H1, 5HT2A/2C, 5HT3, 5HT6 (Ki=7, 4, 11, 57, and 5 nM, respectively), dopamine D1-4 (Ki=11 to 31 nM), muscarinic M1-5 (Ki=1.9-25 nM), and adrenergic α1 receptors (Ki=19 nM). Olanzapine is an atypical antipsychotic[1][2].

IC50 & Target

D3 Receptor

 

mAChR1

 

Molecular Weight

315.45

Formula

C17H17D3N4S
CAS No.
Unlabeled CAS
Appearance

Solid

Color

White to yellow

SMILES

[2H]C(N1CCN(C2=NC3=CC=CC=C3NC4=C2C=C(C)S4)CC1)([2H])[2H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (63.40 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.1701 mL 15.8504 mL 31.7007 mL
5 mM 0.6340 mL 3.1701 mL 6.3401 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
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Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.1701 mL 15.8504 mL 31.7007 mL 79.2519 mL
5 mM 0.6340 mL 3.1701 mL 6.3401 mL 15.8504 mL
10 mM 0.3170 mL 1.5850 mL 3.1701 mL 7.9252 mL
15 mM 0.2113 mL 1.0567 mL 2.1134 mL 5.2835 mL
20 mM 0.1585 mL 0.7925 mL 1.5850 mL 3.9626 mL
25 mM 0.1268 mL 0.6340 mL 1.2680 mL 3.1701 mL
30 mM 0.1057 mL 0.5283 mL 1.0567 mL 2.6417 mL
40 mM 0.0793 mL 0.3963 mL 0.7925 mL 1.9813 mL
50 mM 0.0634 mL 0.3170 mL 0.6340 mL 1.5850 mL
60 mM 0.0528 mL 0.2642 mL 0.5283 mL 1.3209 mL
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Olanzapine-d3 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Olanzapine-d3786686-79-1LY170053-d35-HT ReceptorDopamine ReceptormAChRAdrenergic ReceptorAutophagyMitophagyApoptosisSerotonin Receptor5-hydroxytryptamine ReceptorMuscarinic acetylcholine receptorBeta ReceptorMitochondrial AutophagyInhibitorinhibitorinhibit

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