2. Apoptosis Metabolic Enzyme/Protease
  3. Apoptosis Endogenous Metabolite
  4. Ompenaclid

Ompenaclid  (Synonyms: RGX-202; 3-Guanidinopropionic acid)

Cat. No.: HY-W015828 Purity: ≥98.0%
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Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy.

For research use only. We do not sell to patients.

Ompenaclid Chemical Structure

Ompenaclid Chemical Structure

CAS No. : 353-09-3

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
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Based on 1 publication(s) in Google Scholar

Ompenaclid Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Ompenaclid

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Ompenaclid (RGX-202) is an oral small-molecule SLC6A8 transporter inhibitor. Ompenaclid robustly inhibits creatine import in vitro and in vivo, reduces intracellular phosphocreatine and ATP levels, and induces tumor apoptosis. Ompenaclid can be used for the research of cancer and duchenne muscular dystrophy[1][2].

IC50 & Target

Human Endogenous Metabolite

 

In Vitro

Ompenaclid (RGX-202; 10 μM; 96 hours) reduces cell growth, and reveals a nearly complete depletion of phosphocreatine (>99%), greater than 79% reduction in cellular creatine and a substantial (46%) reduction in intracellular ATP levels relative to control cells in hypoxia[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Ompenaclid Related Antibodies
In Vivo

Ompenaclid (RGX-202; 800 mg/kg; p.o. for 35 days) reduces UN-KPC-961 pancreatic tumoral creatine levels in B6129SF1/J mice[1].
? Ompenaclid (approximately 650 mg/kg; i.p. daily for 14 days) treatment reduces Lvm3b cells liver metastatic colonization by eightfold in NOD-SCID mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: UN-KPC-961 pancreatic tumor-bearing B6129SF1/J mice[1]
Dosage: 800 mg/kg
Administration: p.o. for 35 days
Result: Suppressed tumoral d3-creatine import by 50% at 800 mg/kg.
Animal Model: 6- to 9-week-old C57BL/6J male wild-type mice[1]
Dosage: 100, 250, 500 mg/KG in sterile 0.9% NaCl
Administration: p.o. for 35 days
Result: Inhibited tissue uptake of d3-creatine in a dose-dependent manner by up to 75% at 500 mg/kg.
Clinical Trial
Molecular Weight

131.14

Formula

C4H9N3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(O)CCNC(N)=N
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (381.27 mM)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 7.6254 mL 38.1272 mL 76.2544 mL
5 mM 1.5251 mL 7.6254 mL 15.2509 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: ≥98.0%

COA (242 KB) HNMR (222 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 7.6254 mL 38.1272 mL 76.2544 mL 190.6360 mL
5 mM 1.5251 mL 7.6254 mL 15.2509 mL 38.1272 mL
10 mM 0.7625 mL 3.8127 mL 7.6254 mL 19.0636 mL
15 mM 0.5084 mL 2.5418 mL 5.0836 mL 12.7091 mL
20 mM 0.3813 mL 1.9064 mL 3.8127 mL 9.5318 mL
25 mM 0.3050 mL 1.5251 mL 3.0502 mL 7.6254 mL
30 mM 0.2542 mL 1.2709 mL 2.5418 mL 6.3545 mL
40 mM 0.1906 mL 0.9532 mL 1.9064 mL 4.7659 mL
50 mM 0.1525 mL 0.7625 mL 1.5251 mL 3.8127 mL
60 mM 0.1271 mL 0.6355 mL 1.2709 mL 3.1773 mL
80 mM 0.0953 mL 0.4766 mL 0.9532 mL 2.3829 mL
100 mM 0.0763 mL 0.3813 mL 0.7625 mL 1.9064 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Ompenaclid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Ompenaclid353-09-3RGX-202 3-Guanidinopropionic acidRGX202RGX 202ApoptosisEndogenous Metaboliteoralapoptosiscancercreatine importmiceUN-KPC-961 cellsInhibitorinhibitorinhibit

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