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Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine.

For research use only. We do not sell to patients.

Org 43553 Chemical Structure

Org 43553 Chemical Structure

CAS No. : 501444-88-8

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Based on 1 publication(s) in Google Scholar

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Description

Org 43553 is an orally active and low molecular weight (LMW) luteinizing hormone receptor (LH-R) agonist. Org 43553 shows agonistic activity to human LH and FSH receptors with EC50 values of 3.7 and 110 nM, respectively. Org 43553 can be used for the research of endocrine[1].

In Vitro

Org 43553 (0-3 μM; 4 h) shows agonistic activity to human LH, FSH and TSH receptors[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Org 43553 Related Antibodies

Cell Viability Assay[1]

Cell Line: CHO and HEK293 cell lines
Concentration: 0-3 μM
Incubation Time: 4 hours
Result: Exhibited agonistic activity to human LH, FSH and TSH receptors with EC50 values of 3.7 nM, 110 nM and ＞3 μM, respectively. Showed no CRF1-R agonistic effect in CHO-CRF1 cell line.
In Vivo

Org 43553 (5-50 mg/kg; p.o. once) triggers ovulation in immature mice and increases ovulation in GnRH-antagonist-treated rats[1].
Org 43553 (10-250 mg/kg; p.o. once) increases testosterone levels in male rats[1].
1.19 Pharmacokinetic Properties of Org 43553 in Rats and Dogs[1].

Rats
IV 5 mg/kg		 Rats
PO 50 mg/kg		 Dogs
IV 12.5 mg/kg		 Dogs
PO 50 mg/kg
AUC (h mg/L) 6.9±0.4 55.1±2.0 9.1±3.1 16.1±1.2
Tmax (h) 3.3±3.3 0.9±1.0
Cmax (mg/L) 5.1±2.3 3.8±0.9 8.7±2.2 4.1±1.7
t1/2 (h) 3.4±1.3 4.5±1.8 1.5±1.3 3.5±2.5
CL (L/h) 0.7±0.1 0.9±0.1 1.5±0.6 3.1±0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Immature Humegon primed mice and GnRH-antagonist-treated female Orga rats [1]
Dosage: 5-50 mg/kg
Administration: Oral gavage; 50 mg/kg once
Result: Triggered ovulation in 80% of the animals, with a mean number of 9.3 ova per ovulating animals. Dose-dependently increased the number of ovulated oocytes in the ampulla, and showed a similar ovulation number at a dose of 25 mg/kg compared with hCG group.
Animal Model: Adult male rats[1]
Dosage: 10, 50 and 250 mg/kg
Administration: Oral gavage; 10-250 mg/kg once
Result: Significantly increased testosterone production in male rats and at a dose of 250 mg/kg the testosterone levels were very similar to those induced by hCG.
Molecular Weight

514.66

Formula

C24H30N6O3S2
CAS No.
SMILES

O=C(C1=C(N)C2=C(C3=CC=CC(NC(CN4CCOCC4)=O)=C3)N=C(SC)N=C2S1)NC(C)(C)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Org 43553501444-88-8Org43553Org-43553Othersoralovulation inductionARTOHSStestosteroneInhibitorinhibitorinhibit

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