2. GPCR/G Protein Neuronal Signaling
  3. Dopamine Receptor
  4. OS-3-106

OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 can be used for psychoactivator addiction research.

For research use only. We do not sell to patients.

OS-3-106 Chemical Structure

OS-3-106 Chemical Structure

CAS No. : 1580000-17-4

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10 mg USD 105 In-stock
25 mg USD 220 In-stock
50 mg USD 380 In-stock
100 mg USD 650 In-stock
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Based on 1 publication(s) in Google Scholar

OS-3-106 Related Antibodies

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Description

OS-3-106 is a potent, BBB-penetrated and selective dopamine D3 receptor (D3R) agonist. OS-3-106 binds with high affinity (Ki = 0.2 nM) at the D3R. OS-3-106 can be used for psychoactivator addiction research[1].

IC50 & Target

D3 Receptor

0.2 nM (Ki)

D2 Receptor

 

In Vitro

OS-3-106 exhibits 115-fold binding selectivity for the D3R compared with the D2R[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

OS-3-106 Related Antibodies
Molecular Weight

450.60

Formula

C25H30N4O2S
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(NCCCCN1CCN(C2=CC=CC=C2OC)CC1)C3=CC=C(C4=CSC=N4)C=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 83.33 mg/mL (184.93 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.2193 mL 11.0963 mL 22.1926 mL
5 mM 0.4439 mL 2.2193 mL 4.4385 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.2193 mL 11.0963 mL 22.1926 mL 55.4816 mL
5 mM 0.4439 mL 2.2193 mL 4.4385 mL 11.0963 mL
10 mM 0.2219 mL 1.1096 mL 2.2193 mL 5.5482 mL
15 mM 0.1480 mL 0.7398 mL 1.4795 mL 3.6988 mL
20 mM 0.1110 mL 0.5548 mL 1.1096 mL 2.7741 mL
25 mM 0.0888 mL 0.4439 mL 0.8877 mL 2.2193 mL
30 mM 0.0740 mL 0.3699 mL 0.7398 mL 1.8494 mL
40 mM 0.0555 mL 0.2774 mL 0.5548 mL 1.3870 mL
50 mM 0.0444 mL 0.2219 mL 0.4439 mL 1.1096 mL
60 mM 0.0370 mL 0.1849 mL 0.3699 mL 0.9247 mL
80 mM 0.0277 mL 0.1387 mL 0.2774 mL 0.6935 mL
100 mM 0.0222 mL 0.1110 mL 0.2219 mL 0.5548 mL
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OS-3-106 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OS-3-1061580000-17-4Dopamine Receptorarylamide phenylpiperazineHEK 293 cellssucrosepsychostimulant addictionself-administrationInhibitorinhibitorinhibit

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