2. Metabolic Enzyme/Protease Apoptosis
  3. Lactate Dehydrogenase Apoptosis
  4. Oxamic acid

Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis.

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Oxamic acid Chemical Structure

Oxamic acid Chemical Structure

CAS No. : 471-47-6

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Based on 7 publication(s) in Google Scholar

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Oxamic acid Related Antibodies

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Description

Oxamic acid is a lactate dehydrogenase-A (LDH-A) inhibitor. Oxamic acid shows anti-tumor activity, and anti-proliferative activity against cancer cells, and can induce apoptosis[1][2][3].

In Vitro

Oxamic acid suppresses the proliferation, migration and invasion of both A2780 and SKOV3 cells[1].
Oxamic acid (10 μM; 24-72 h) inhibits cell proliferation in a dose- and time-dependent manner in both NPC cancer cells[2].
Oxamic acid (0-100 mM; 24 h) induces cell cycle arrest in the G2/M phase in CNE-1 and CNE-2 cells[2].
Oxamic acid (0-100 mM; 48 h) induces apoptosis via caspase-3 activation and the mitochondrial pathway in NPC cells[2].
Oxamic acid (0-100 mM; 24 h) increases ROS levels in NPC cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Oxamic acid Related Antibodies

Cell Proliferation Assay[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 10 μM
Incubation Time: 24-72 hours
Result: Showed IC50s of 74.6, 32.4 and 17.8 mM and 62.3, 44.5, 31.6 mM at 24, 48 and 72 h in the CNE-1 and CNE-2 cancer cells, respectively.

Apoptosis Analysis[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 48 hours
Result: Showed the increasement of early and late apoptotic cells in a dose-dependent manner.
Increased the expression of pro-apoptotic Bax and cleaved-caspase-3, while reduced the anti-apoptotic signals of Bcl-2 and pro-caspase-3.

Cell Cycle Analysis[2]

Cell Line: CNE-1 and CNE-2 cells
Concentration: 0, 20, 50 and 100 mM
Incubation Time: 24 hours
Result: Showed a dose-dependent increase in the numbers of CNE-1 and CNE-2 cells in the G2/M phase.
In Vivo

Oxamic acid (intraperitoneal injection; 750 mg/kg; once daily; 3 w) treatment improves the efficacy of tumor inhibition in vivo when combined with irradiation treatment[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Balb/c nude mice injected with CNE-1 cells[2]
Dosage: 750 mg/kg
Administration: Intraperitoneal injection; 750 mg/kg; once daily; 3 weeks
Result: Inhibited the tumor growth when compared to either oxamate alone or irradiation alone.
Molecular Weight

89.05

Formula

C2H3NO3
CAS No.
SMILES

NC(C(O)=O)=O
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Solvent & Solubility
In Vitro: 

H2O : 125 mg/mL (1403.71 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 11.2296 mL 56.1482 mL 112.2965 mL
5 mM 2.2459 mL 11.2296 mL 22.4593 mL
View the Complete Stock Solution Preparation Table

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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This equation is commonly abbreviated as: C1V1 = C2V2

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This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
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Purity & Documentation
References

Complete Stock Solution Preparation Table

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 11.2296 mL 56.1482 mL 112.2965 mL 280.7411 mL
5 mM 2.2459 mL 11.2296 mL 22.4593 mL 56.1482 mL
10 mM 1.1230 mL 5.6148 mL 11.2296 mL 28.0741 mL
15 mM 0.7486 mL 3.7432 mL 7.4864 mL 18.7161 mL
20 mM 0.5615 mL 2.8074 mL 5.6148 mL 14.0371 mL
25 mM 0.4492 mL 2.2459 mL 4.4919 mL 11.2296 mL
30 mM 0.3743 mL 1.8716 mL 3.7432 mL 9.3580 mL
40 mM 0.2807 mL 1.4037 mL 2.8074 mL 7.0185 mL
50 mM 0.2246 mL 1.1230 mL 2.2459 mL 5.6148 mL
60 mM 0.1872 mL 0.9358 mL 1.8716 mL 4.6790 mL
80 mM 0.1404 mL 0.7019 mL 1.4037 mL 3.5093 mL
100 mM 0.1123 mL 0.5615 mL 1.1230 mL 2.8074 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Oxamic acid Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Oxamic acid471-47-6Oxamidic acidLactate DehydrogenaseApoptosisLDHanti-tumor activityanti-proliferative activityinduce apoptosisCNE-1CNE-2A2780SKOV3Inhibitorinhibitorinhibit

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