2. Apoptosis
  3. Apoptosis
  4. p-Tolylmaleimide

p-Tolylmaleimide (compound 9) is a naphthalimide derivative that has cytotoxic effects on cancer cells. p-Tolylmaleimide can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis.

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p-Tolylmaleimide Chemical Structure

p-Tolylmaleimide Chemical Structure

CAS No. : 1631-28-3

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p-Tolylmaleimide Related Antibodies

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Description

p-Tolylmaleimide (compound 9) is a naphthalimide derivative that has cytotoxic effects on cancer cells. p-Tolylmaleimide can arrest the cell cycle of human acute myeloid leukemia cells K562 in the sub-G0/G1 phase and induce apoptosis[1].

In Vitro

p-Tolylmaleimide inhibits human acute myeloid leukemia cell K562 with IC50s of 24.99 μM (24 h), 6.61 (48 h), and 12.10 (72 h) respectively. p-Tolylmaleimide for inhibits human acute myeloid leukemia cell Jurkat with IC50s of 27.16 μM (24 h), 15.51 (48 h), and 3.94 (72 h) respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p-Tolylmaleimide Related Antibodies
Molecular Weight

187.19

Formula

C11H9NO2
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C=C1)N(C2=CC=C(C)C=C2)C1=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Purity & Documentation

Purity: ≥98.0%

COA (256 KB) HNMR (128 KB)

Handling Instructions (2659 KB)
References
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p-Tolylmaleimide Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p-Tolylmaleimide1631-28-3ApoptosisHuman acute myeloid leukemia cellsnaphthalimideInhibitorinhibitorinhibit

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