2. MAPK/ERK Pathway
  3. p38 MAPK
  4. p38 MAP Kinase Inhibitor IV

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively.

For research use only. We do not sell to patients.

p38 MAP Kinase Inhibitor IV Chemical Structure

p38 MAP Kinase Inhibitor IV Chemical Structure

CAS No. : 1638-41-1

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Based on 1 publication(s) in Google Scholar

p38 MAP Kinase Inhibitor IV Related Antibodies

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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Description

p38 MAP Kinase Inhibitor IV is a highly specific ATP-competitive p38α MAPK inhibitor with IC50s of 0.13 and 0.55 μM for p38α and p38β MAPK, respectively[1].

IC50 & Target

p38α

0.13 μM (IC50)

p38β

0.55 μM (IC50)

p38δ

8.63 μM (IC50)

p38χ

5.47 μM (IC50)

In Vitro

p38 MAP Kinase Inhibitor IV (MT4) shows IC50 values of 0.13, 0.55, 5.47, and 8.63μM for p38α, β, χ, andδ, respectively. p38 MAP Kinase Inhibitor IV has the suppressive action on the release of TNF-alpha and IL-1beta in PBMC with IC50 values of 22 and 44 nM, respectively[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

p38 MAP Kinase Inhibitor IV Related Antibodies
Molecular Weight

456.94

Formula

C12H4Cl6O4S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

OC1=C(Cl)C=C(Cl)C(Cl)=C1S(=O)(C2=C(O)C(Cl)=CC(Cl)=C2Cl)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation

Purity: 98.0%

SDS (393 KB)

COA (256 KB)

Handling Instructions (2659 KB)
References
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p38 MAP Kinase Inhibitor IV Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p38 MAP Kinase Inhibitor IV1638-41-1p38 MAPKTNF-αLPSPBMCanti-inflammatoryATP-competitiveInhibitorinhibitorinhibit

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