2. Cell Cycle/DNA Damage Epigenetics
  3. HDAC
  4. PB94

PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications.

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PB94 Chemical Structure

PB94 Chemical Structure

CAS No. : 3032970-74-1

Size Price Stock Quantity
5 mg USD 245 In-stock
10 mg USD 390 In-stock
25 mg USD 780 In-stock
50 mg USD 1250 In-stock
100 mg USD 1980 In-stock
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Based on 1 publication(s) in Google Scholar

PB94 Related Antibodies

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View All HDAC Isoform Specific Products:

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HDAC HDAC1 HDAC2 HDAC3 HDAC4 HDAC5 HDAC6 HDAC7 HDAC8 HDAC9 HDAC10 HDAC11 HD1 HD2

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Description

PB94 is a selective HDAC11 inhibitor (IC50=108 nM). PB94 can be radiolabeled as [11C]-PB94 for use in positron emission tomography (PET), as well as brain uptake and metabolic properties in administered live animals. PB94 improves neuropathic pain in mice and could be used to study neurological indications[1].

IC50 & Target

IC50: 108 nM (HDAC11)[1]
Molecular Weight

487.59

Formula

C29H33N3O4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CC=C2C(C=CN2CC(C=C3)=CC(OC)=C3C(NO)=O)=C1)NCC4(C[C@@H](C5)C6)C[C@@H]6C[C@@H]5C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 87.5 mg/mL (179.45 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.0509 mL 10.2545 mL 20.5090 mL
5 mM 0.4102 mL 2.0509 mL 4.1018 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.0509 mL 10.2545 mL 20.5090 mL 51.2726 mL
5 mM 0.4102 mL 2.0509 mL 4.1018 mL 10.2545 mL
10 mM 0.2051 mL 1.0255 mL 2.0509 mL 5.1273 mL
15 mM 0.1367 mL 0.6836 mL 1.3673 mL 3.4182 mL
20 mM 0.1025 mL 0.5127 mL 1.0255 mL 2.5636 mL
25 mM 0.0820 mL 0.4102 mL 0.8204 mL 2.0509 mL
30 mM 0.0684 mL 0.3418 mL 0.6836 mL 1.7091 mL
40 mM 0.0513 mL 0.2564 mL 0.5127 mL 1.2818 mL
50 mM 0.0410 mL 0.2051 mL 0.4102 mL 1.0255 mL
60 mM 0.0342 mL 0.1709 mL 0.3418 mL 0.8545 mL
80 mM 0.0256 mL 0.1282 mL 0.2564 mL 0.6409 mL
100 mM 0.0205 mL 0.1025 mL 0.2051 mL 0.5127 mL
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PB94 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PB943032970-74-1PB 94PB-94HDACHistone deacetylasesPositron Emission Computed TomographyPETInhibitorinhibitorinhibit

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