2. MAPK/ERK Pathway
  3. MEK
  4. PD-334581

PD-334581 is a MEK1 inhibitor.

For research use only. We do not sell to patients.

PD-334581 Chemical Structure

PD-334581 Chemical Structure

CAS No. : 548756-68-9

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1 mg USD 110 In-stock
5 mg USD 385 In-stock
10 mg USD 655 In-stock
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Based on 1 publication(s) in Google Scholar

PD-334581 Related Antibodies

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MEK1 MEK2 MEK5 MEK

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Description

PD-334581 is a MEK1 inhibitor[1].

IC50 & Target

MEK1

 

Molecular Weight

545.30

Formula

C20H19F3IN5O2
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

FC1=C(F)C(NC2=CC=C(C=C2F)I)=C(C3=NN=C(NCCN4CCOCC4)O3)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 12.5 mg/mL (22.92 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8339 mL 9.1693 mL 18.3385 mL
5 mM 0.3668 mL 1.8339 mL 3.6677 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.8339 mL 9.1693 mL 18.3385 mL 45.8463 mL
5 mM 0.3668 mL 1.8339 mL 3.6677 mL 9.1693 mL
10 mM 0.1834 mL 0.9169 mL 1.8339 mL 4.5846 mL
15 mM 0.1223 mL 0.6113 mL 1.2226 mL 3.0564 mL
20 mM 0.0917 mL 0.4585 mL 0.9169 mL 2.2923 mL
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PD-334581 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD-334581548756-68-9PD334581PD 334581MEKMitogen-activated protein kinase kinaseMAPKKMAP2KInhibitorinhibitorinhibit

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