2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor Dopamine Receptor
  4. Perospirone

Perospirone  (Synonyms: SM-9018 free base)

Cat. No.: HY-B0731A Purity: 99.43%
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Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research.

For research use only. We do not sell to patients.

Perospirone Chemical Structure

Perospirone Chemical Structure

CAS No. : 150915-41-6

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Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
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10 mg USD 132 In-stock
50 mg USD 462 In-stock
100 mg USD 792 In-stock
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Based on 1 publication(s) in Google Scholar

Other Forms of Perospirone:

Perospirone Related Antibodies

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Description

Perospirone (SM-9018 free base) is an orally active antagonist of 5-HT2A receptor (Ki=0.6 nM) and dopamine D2 receptor (Ki=1.4 nM), and also a partial agonist of 5-HT1A receptor (Ki=2.9 nM). Perospirone is an atypical antipsychotic agent and has the potential for schizophrenic disease research[1][2].

IC50 & Target[1][2]

5-HT2A Receptor

0.6 nM (Ki)

Dopamine D2

1.4 nM (Ki)

5-HT1A Receptor

2.9 nM (Ki)

5-HT1 Receptor

18 nM (Ki)

Dopamine D1

41 nM (Ki)

In Vitro

Perospirone (SM-9018 free base) possesses moderate affinities for α1, 5-HT1, and D1 receptors (Ki=17, 18 and 41 nM, respectively) [1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Perospirone Related Antibodies
In Vivo

Perospirone (SM-9018 free base; 1.0-10.0 mg/kg/day; orally; for 14 consecutive days) significantly attenuates PCP-induced cognitive deficits in mice in a dose-dependent manner[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male ICR mice (6 weeks old) weighing 25-30 g[2]
Dosage: 1.0, 3.0 or 10.0 mg/kg
Administration: Orally; daily; for 14 consecutive days
Result: Significantly attenuated PCP-induced cognitive deficits in mice in a dose-dependent manner.
Clinical Trial
Molecular Weight

426.57

Formula

C23H30N4O2S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C([C@@]1([H])[C@]2([H])CCCC1)N(C2=O)CCCCN3CCN(C4=NSC5=C4C=CC=C5)CC3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 2 years
-20°C 1 year
Solvent & Solubility
In Vitro: 

DMSO : 5 mg/mL (11.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3443 mL 11.7214 mL 23.4428 mL
5 mM 0.4689 mL 2.3443 mL 4.6886 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 2 years; -20°C, 1 year. When stored at -80°C, please use it within 2 years. When stored at -20°C, please use it within 1 year.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3443 mL 11.7214 mL 23.4428 mL 58.6070 mL
5 mM 0.4689 mL 2.3443 mL 4.6886 mL 11.7214 mL
10 mM 0.2344 mL 1.1721 mL 2.3443 mL 5.8607 mL
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Perospirone Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Perospirone150915-41-6SM-9018SM9018SM 90185-HT ReceptorDopamine ReceptorSerotonin Receptor5-hydroxytryptamine ReceptorOrallyatypicalantipsychoticschizophrenicdiseasecognitivedeficitsInhibitorinhibitorinhibit

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