Phytoene desaturase-IN-1

Name: Phytoene desaturase-IN-1
Brand: MedChemExpress
SKU: HY-151095
Rating: 4.5 (1 reviews)

Cat. No.: HY-151095 Purity: 99.59%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

Phytoene desaturase-IN-1 is a potent phytoene desaturase (PDS) inhibitor (K_d: 65.9 μM) through π−π stacking effect with Phe301 residue. Phytoene desaturase-IN-1 shows broad spectrum of postemergence herbicidal activity. Phytoene desaturase-IN-1 induces PDS mRNA reduction, phytoene and reactive oxygen species (ROS) accumulation in albino leaves. Phytoene desaturase-IN-1 can be used in the area of agricultural production.

For research use only. We do not sell to patients.

Phytoene desaturase-IN-1 Chemical Structure

CAS No. : 2765793-54-0

Size	Price	Stock	Quantity
5 mg	USD 150	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 240	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
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Description

IC₅₀ & Target

Phytoene desaturase (PDS), reactive oxygen species (ROS)^[1].

In Vitro

Phytoene desaturase-IN-1 (1b, 375−750 g/ha, 25 days) shows a broad spectrum of herbicidal activity against six kinds of weeds (including ECHCG, DIGSA, SETFA, ABUJU, AMARE, and ECLPR)^[1].
Phytoene desaturase-IN-1 (750 g/ha, 14 days) down-regulates PDS mRNA level and induces phytoene accumulation, with the observed albino leaf phenotype^[1].
Phytoene desaturase-IN-1 (750 g/ha, 3 days) induces ROS accumulation and regulates ROS-associated enzymes activity^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	Albino leaves
Concentration:	750 g/ha
Incubation Time:	14 days
Result:	Reduced PDS mRNA level by 30%, thereby limiting the catalytic dehydrogenation process of phytoene and causing phytoene accumulation.

Molecular Weight

427.83

Formula

C₁₈H₁₃ClF₃N₃O₂S

CAS No.

2765793-54-0

Appearance

Solid

Color

Off-white to light yellow

SMILES

O=C(C1=CC=C(Cl)C=C1)CSC2=NN=C(CO)N2C3=CC=CC(C(F)(F)F)=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

Solvent & Solubility

In Vitro:

DMSO : 125 mg/mL (292.17 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.3374 mL	11.6869 mL	23.3738 mL
5 mM	0.4675 mL	2.3374 mL	4.6748 mL
10 mM	0.2337 mL	1.1687 mL	2.3374 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

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Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.59%

Select Batch:

Data Sheet (276 KB) SDS (251 KB)

COA (253 KB) HNMR (256 KB) LCMS (91 KB)

Handling Instructions (2659 KB)

References

[1]. Di Zhang, et al. Discovery of (5-(Benzylthio)-4-(3-(trifluoromethyl)phenyl)-4 H-1,2,4-triazol-3-yl) Methanols as Potent Phytoene Desaturase Inhibitors through Virtual Screening and Structure Optimization. J Agric Food Chem. 2022 Aug 10. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.3374 mL	11.6869 mL	23.3738 mL	58.4344 mL
	5 mM	0.4675 mL	2.3374 mL	4.6748 mL	11.6869 mL
	10 mM	0.2337 mL	1.1687 mL	2.3374 mL	5.8434 mL
	15 mM	0.1558 mL	0.7791 mL	1.5583 mL	3.8956 mL
	20 mM	0.1169 mL	0.5843 mL	1.1687 mL	2.9217 mL
	25 mM	0.0935 mL	0.4675 mL	0.9350 mL	2.3374 mL
	30 mM	0.0779 mL	0.3896 mL	0.7791 mL	1.9478 mL
	40 mM	0.0584 mL	0.2922 mL	0.5843 mL	1.4609 mL
	50 mM	0.0467 mL	0.2337 mL	0.4675 mL	1.1687 mL
	60 mM	0.0390 mL	0.1948 mL	0.3896 mL	0.9739 mL
	80 mM	0.0292 mL	0.1461 mL	0.2922 mL	0.7304 mL
	100 mM	0.0234 mL	0.1169 mL	0.2337 mL	0.5843 mL