2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. Pipendoxifene

Pipendoxifene  (Synonyms: ERA-923)

Cat. No.: HY-13724 Purity: 99.02%
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Pipendoxifene is a selective estrogen receptor modulator (SERM).

For research use only. We do not sell to patients.

Pipendoxifene Chemical Structure

Pipendoxifene Chemical Structure

CAS No. : 198480-55-6

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5 mg USD 140 In-stock
10 mg USD 230 In-stock
25 mg USD 480 In-stock
50 mg USD 800 In-stock
100 mg USD 1350 In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Pipendoxifene:

Pipendoxifene Related Antibodies

Top Publications Citing Use of Products

View All Estrogen Receptor/ERR Isoform Specific Products:

View All Isoforms
Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

  • Biological Activity

  • Purity & Documentation

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Description

Pipendoxifene is a selective estrogen receptor modulator (SERM).

IC50 & Target

Estrogen receptor[1]
Cellular Effect
Cell Line Type Value Description References
MCF7 EC50
0.0001 μM
Compound: 6
Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assay
Induction of estrogen receptor-alpha degradation in human MCF7 cells after 4 hrs by in-cell western assay
[PMID: 25879485]
MCF7 IC50
0.4 μM
Compound: 6
Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by CellTiter-Glo assay
Cytotoxicity against human MCF7 cells assessed as cell viability after 5 days by CellTiter-Glo assay
[PMID: 25879485]
MCF7 IC50
0.6 nM
Compound: 6
Antagonist activity at estrogen receptor in human MCF7 cells assessed as inhibition of 17beta-estradiol-mediated transcriptional activation after 24 hrs by luciferase reporter gene assay
Antagonist activity at estrogen receptor in human MCF7 cells assessed as inhibition of 17beta-estradiol-mediated transcriptional activation after 24 hrs by luciferase reporter gene assay
[PMID: 25879485]
In Vitro

Pipendoxifene is a new 2-phenyl indole selective estrogen receptor modulators (SERM) that exhibits an excellent preclinical pharmacological profile and is selected for further development as a treatment for metastatic breast cancer[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pipendoxifene Related Antibodies
Molecular Weight

456.58

Formula

C29H32N2O3
CAS No.
Appearance

Solid

Color

Off-white to light yellow

SMILES

OC1=CC2=C(N(CC3=CC=C(OCCN4CCCCC4)C=C3)C(C5=CC=C(O)C=C5)=C2C)C=C1
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (219.02 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.1902 mL 10.9510 mL 21.9020 mL
5 mM 0.4380 mL 2.1902 mL 4.3804 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration
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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.1902 mL 10.9510 mL 21.9020 mL 54.7549 mL
5 mM 0.4380 mL 2.1902 mL 4.3804 mL 10.9510 mL
10 mM 0.2190 mL 1.0951 mL 2.1902 mL 5.4755 mL
15 mM 0.1460 mL 0.7301 mL 1.4601 mL 3.6503 mL
20 mM 0.1095 mL 0.5475 mL 1.0951 mL 2.7377 mL
25 mM 0.0876 mL 0.4380 mL 0.8761 mL 2.1902 mL
30 mM 0.0730 mL 0.3650 mL 0.7301 mL 1.8252 mL
40 mM 0.0548 mL 0.2738 mL 0.5475 mL 1.3689 mL
50 mM 0.0438 mL 0.2190 mL 0.4380 mL 1.0951 mL
60 mM 0.0365 mL 0.1825 mL 0.3650 mL 0.9126 mL
80 mM 0.0274 mL 0.1369 mL 0.2738 mL 0.6844 mL
100 mM 0.0219 mL 0.1095 mL 0.2190 mL 0.5475 mL
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Pipendoxifene Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pipendoxifene198480-55-6ERA-923ERA923ERA 923Estrogen Receptor/ERRestrogen receptorInhibitorinhibitorinhibit

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