2. Cell Cycle/DNA Damage
  3. Polo-like Kinase (PLK)
  4. PLK4-IN-1

PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM.

For research use only. We do not sell to patients.

PLK4-IN-1 Chemical Structure

PLK4-IN-1 Chemical Structure

CAS No. : 1247001-12-2

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of PLK4-IN-1:

PLK4-IN-1 Related Antibodies

Top Publications Citing Use of Products

View All Polo-like Kinase (PLK) Isoform Specific Products:

View All Isoforms
PLK1 PLK2 PLK3 PLK4

  • Biological Activity

  • Purity & Documentation

  • References

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Description

PLK4-IN-1 (Example A6) is a PLK4 inhibitor, with an IC50 of ≤ 0.1 μM[1].

IC50 & Target

IC50: ≤ 0.1 μM (PLK4)[1].
Molecular Weight

431.23

Formula

C18H14IN3O2
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@@]12[C@H](C3=CC4=C(C=C3)C(I)=NN4)C1)NC5=C2C=C(OC)C=C5.[Relative stereochemistry]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 260 mg/mL (602.93 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3189 mL 11.5947 mL 23.1895 mL
5 mM 0.4638 mL 2.3189 mL 4.6379 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3189 mL 11.5947 mL 23.1895 mL 57.9737 mL
5 mM 0.4638 mL 2.3189 mL 4.6379 mL 11.5947 mL
10 mM 0.2319 mL 1.1595 mL 2.3189 mL 5.7974 mL
15 mM 0.1546 mL 0.7730 mL 1.5460 mL 3.8649 mL
20 mM 0.1159 mL 0.5797 mL 1.1595 mL 2.8987 mL
25 mM 0.0928 mL 0.4638 mL 0.9276 mL 2.3189 mL
30 mM 0.0773 mL 0.3865 mL 0.7730 mL 1.9325 mL
40 mM 0.0580 mL 0.2899 mL 0.5797 mL 1.4493 mL
50 mM 0.0464 mL 0.2319 mL 0.4638 mL 1.1595 mL
60 mM 0.0386 mL 0.1932 mL 0.3865 mL 0.9662 mL
80 mM 0.0290 mL 0.1449 mL 0.2899 mL 0.7247 mL
100 mM 0.0232 mL 0.1159 mL 0.2319 mL 0.5797 mL
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PLK4-IN-1 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PLK4-IN-11247001-12-2Polo-like Kinase (PLK)PLK4Inhibitorinhibitorinhibit

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