PPAR agonist 5

Cat. No.: HY-163547: FAQs
Data Sheet Handling Instructions

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PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC₅₀ values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect.

For research use only. We do not sell to patients.

PPAR agonist 5 Chemical Structure

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Biological Activity
Purity & Documentation
References
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Description

PPAR agonist 5 (compound 4b) is a potent PPAR agonist with EC₅₀ values of 3.20, 1.51, 1.92 µM for PPARα, PPARβ/δ, PPARγ, respectively. PPAR agonist 5 shows anti-inflammatory effect^[1].

IC₅₀ & Target^[1]

PPARα

3.20 μM (EC₅₀)

PPARβ/δ

1.51 μM (EC₅₀)

PPARγ

1.92 μM (EC₅₀)

In Vitro

PPAR agonist 5 (compound 4b) (10 µM; 4, 24 h) decrease LPS (HY-D1056) induced mRNA expression of CCL-2 and IL-6^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

RT-PCR^[1]

Cell Line:	THP-1 human monocytes differentiated into macrophages
Concentration:	10 µM
Incubation Time:	4, 24 h
Result:	Decreased the LPS (HY-D1056) (10 ng/mL)-induced expression of CCL-2 at 4 and 24 h and the expression of IL-6 at 24 h.

Molecular Weight

403.51

Formula

C₂₆H₂₉NO₃

SMILES

O=C(OCC)CC/C(C)=C/CCC1=NC2=CC=C(OCC3=CC=CC=C3)C=C2C=C1

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation

Handling Instructions (2659 KB)

References

[1]. Villarroel-Vicente C, et al. Synthesis of a new 2-prenylated quinoline as potential drug for metabolic syndrome with pan-PPAR activity and anti-inflammatory effects. Bioorg Med Chem Lett. 2024 Jul 1;106:129770. [Content Brief]

PPAR agonist 5 Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PPAR agonist 5PPAR agonist5PPAR agonist-5PPARPeroxisome proliferator-activated receptorsmacrophagesCCL-2IL-6anti-inflammatoryInhibitorinhibitorinhibit

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