PROTAC AR/AR-V7 degrader-1

Name: PROTAC AR/AR-V7 degrader-1
Brand: MedChemExpress
SKU: HY-162412
Rating: 4.5 (1 reviews)

Cat. No.: HY-162412 Purity: 99.72%: FAQs
Data Sheet SDS COA Handling Instructions

Molarity Calculator

PROTAC AR/AR-V7 degrader-1 (27c) is a PROTAC-based and dual AR, AR-V7 degrader, with DC₅₀ values of 2.67 and 2.64 μM for AR and AR-V7, respectively. PROTAC AR/AR-V7 degrader-1 (27c) induces apoptosis (Red: AR antagonist; Blue: E3 ligase ligand; Black: linker).

For research use only. We do not sell to patients.

PROTAC AR/AR-V7 degrader-1 Chemical Structure

CAS No. : 2841308-96-9

Size	Price	Stock	Quantity
5 mg	USD 480	In-stock	Estimated Time of Arrival: December 31
10 mg	USD 768	In-stock	Estimated Time of Arrival: December 31
25 mg	USD 1500	In-stock	Estimated Time of Arrival: December 31
50 mg		Get quote
100 mg		Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

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Biological Activity
Purity & Documentation
References
Customer Review

Description

In Vitro

PROTAC AR/AR-V7 degrader-1 (27c) effectively suppresses transcriptional activity of the AR signaling pathway. PROTAC AR/AR-V7 degrader-1 (27c) exhibits an IC₅₀ of 0.9 μM in 22RV1 cells^[1].
PROTAC AR/AR-V7 degrader-1 (27c) overcomes drug resistance in advanced PCa expressing AR splice variants^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

485.43

Formula

C₂₄H₁₉F₄N₅O₂

CAS No.

2841308-96-9

Appearance

Solid

Color

Off-white to yellow

SMILES

O=C1C(C)(C)N(CCNC2=C(C=CC=N3)C3=C(F)C=C2)C(N1C4=CC(C(F)(F)F)=C(C#N)C=C4)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, protect from light

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light)

Solvent & Solubility

In Vitro:

DMSO : ≥ 100 mg/mL (206.00 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	2.0600 mL	10.3001 mL	20.6003 mL
5 mM	0.4120 mL	2.0600 mL	4.1201 mL
10 mM	0.2060 mL	1.0300 mL	2.0600 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Molarity Calculator
Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 99.72%

Select Batch:

Data Sheet (272 KB) SDS (252 KB)

COA (248 KB) HNMR (272 KB) RP-HPLC (259 KB) LCMS (138 KB)

Handling Instructions (2659 KB)

References

[1]. Maoxu Xiao, et al. Structure–Activity Relationship (SAR) Studies of Novel Monovalent AR/AR-V7 Dual Degraders with Potent Efficacy against Advanced Prostate Cancer. J. Med. Chem. 2024, 67, 7, 5567-5590.

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	2.0600 mL	10.3001 mL	20.6003 mL	51.5007 mL
	5 mM	0.4120 mL	2.0600 mL	4.1201 mL	10.3001 mL
	10 mM	0.2060 mL	1.0300 mL	2.0600 mL	5.1501 mL
	15 mM	0.1373 mL	0.6867 mL	1.3734 mL	3.4334 mL
	20 mM	0.1030 mL	0.5150 mL	1.0300 mL	2.5750 mL
	25 mM	0.0824 mL	0.4120 mL	0.8240 mL	2.0600 mL
	30 mM	0.0687 mL	0.3433 mL	0.6867 mL	1.7167 mL
	40 mM	0.0515 mL	0.2575 mL	0.5150 mL	1.2875 mL
	50 mM	0.0412 mL	0.2060 mL	0.4120 mL	1.0300 mL
	60 mM	0.0343 mL	0.1717 mL	0.3433 mL	0.8583 mL
	80 mM	0.0258 mL	0.1288 mL	0.2575 mL	0.6438 mL
	100 mM	0.0206 mL	0.1030 mL	0.2060 mL	0.5150 mL